Department of Pharmaceutical Chemistry, Government College University, Faisalabad, Pakistan.
Department of Pharmacy, The Women University, Multan, Pakistan.
Environ Sci Pollut Res Int. 2024 Jun;31(26):37963-37987. doi: 10.1007/s11356-024-33735-7. Epub 2024 May 23.
Exposure to heavy metals in various populations can lead to extensive damage to different organs, as these metals infiltrate and bioaccumulate in the human body, causing metabolic disruptions in various organs. To comprehensively understand the metal homeostasis, inter-organ "traffic," and extensive metabolic alterations resulting from heavy metal exposure, employing complementary analytical methods is crucial. Metabolomics is pivotal in unraveling the intricacies of disease vulnerability by furnishing thorough understandings of metabolic changes linked to different metabolic diseases. This field offers exciting prospects for enhancing the disease prevention, early detection, and tailoring treatment approaches to individual needs. This article consolidates the existing knowledge on disease-linked metabolic pathways affected by the exposure of diverse heavy metals providing concise overview of the underlying impact mechanisms. The main aim is to investigate the connection between the altered metabolic pathways and long-term complex health conditions induced by heavy metals such as diabetes mellitus, cardiovascular diseases, renal disorders, inflammation, neurodegenerative diseases, reproductive risks, and organ damage. Further exploration of common pathways may unveil the shared targets for treating associated pathological conditions. In this article, the role of metabolomics in disease susceptibility is emphasized that metabolomics is expected to be routinely utilized for the diagnosis and monitoring of diseases and practical value of biomarkers derived from metabolomics, as well as determining their appropriate integration into extensive clinical settings.
暴露于各种人群中的重金属可能会导致不同器官的广泛损伤，因为这些金属会渗透并在人体内生物累积，导致各种器官的代谢紊乱。为了全面了解金属内稳态、器官间“交通”以及重金属暴露导致的广泛代谢改变，采用互补的分析方法至关重要。代谢组学通过提供与不同代谢疾病相关的代谢变化的全面理解，在揭示疾病易感性的复杂性方面发挥着关键作用。该领域为增强疾病预防、早期检测以及针对个体需求定制治疗方法提供了令人兴奋的前景。本文综合了现有关于受不同重金属暴露影响的与疾病相关的代谢途径的知识，提供了对潜在影响机制的简要概述。主要目的是研究代谢途径的改变与重金属引起的长期复杂健康状况（如糖尿病、心血管疾病、肾脏疾病、炎症、神经退行性疾病、生殖风险和器官损伤）之间的联系。对共同途径的进一步探索可能揭示出针对相关病理状况的共同治疗靶点。本文强调了代谢组学在疾病易感性中的作用，预计代谢组学将被常规用于疾病的诊断和监测，以及源自代谢组学的生物标志物的实际价值，以及确定它们在广泛临床环境中的适当整合。
