Department of Ophtalmatology, Balıkesir Atatürk City Hospital, Altıeylül, Balıkesir, Turkey.
Kırşehir Ahi Evran Training and Research Hospital, Kırşehir, Turkey.
Int Ophthalmol. 2024 May 23;44(1):228. doi: 10.1007/s10792-024-03059-z.
It is known that a healthy and balanced diet plays an important role in the etiopathogenesis of age-related macular degeneration (AMD). The aim of this study is to show the possible relationship between the prognostic nutritional index (PNI) and AMD.
This observational longitudinal study included 50 patients who were diagnosed with AMD and 100 participants as control group in the Ophthalmology Polyclinic of Kırşehir Ahi Evran Training and Research Hospital between December 2022 and February 2023. The PNI scores of the patients were calculated with the formula (10 × albumin (g/L) + (0.005 × total lymphocyte count), using routine hemogram and biochemical assays.
One hundred fifty participants were included in the study (average age: 73.7 ± 8.6 years, male: 53.3%). When adjusted for age, sex, and total comorbidity index score via multivariate logistic regression analysis, the association between AMD and PNI scores (OR = 0.3; CI: 0.2-0.4; p = 0.01) and Charlson Comorbidity Index (CCI) scores (OR = 6.8; CI: 2.8-16.6; p = 0.01) was statistically significant.
The use of PNI scores may be practical and useful in routine clinical practice for predicting AMD.
众所周知，健康均衡的饮食在年龄相关性黄斑变性（AMD）的发病机制中起着重要作用。本研究旨在探讨预后营养指数（PNI）与 AMD 之间的可能关系。
这是一项观察性纵向研究，纳入了 2022 年 12 月至 2023 年 2 月期间在基尔希埃拉·埃夫兰培训与研究医院眼科门诊部被诊断为 AMD 的 50 名患者和 100 名对照组参与者。通过常规血常规和生化检测，用公式（10×白蛋白（g/L）+（0.005×总淋巴细胞计数）计算患者的 PNI 评分。
本研究共纳入 150 名参与者（平均年龄：73.7±8.6 岁，男性：53.3%）。通过多变量逻辑回归分析，校正年龄、性别和总合并症指数评分后，AMD 与 PNI 评分（OR=0.3；95%CI：0.2-0.4；p=0.01）和 Charlson 合并症指数（CCI）评分（OR=6.8；95%CI：2.8-16.6；p=0.01）之间存在统计学显著关联。
PNI 评分的使用可能在预测 AMD 的常规临床实践中具有实用性和有用性。
