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微秒脉冲磁场与 FeO 颗粒联合作用杀伤 A375 黑色素瘤细胞的特性匹配。

Feature Matching of Microsecond-Pulsed Magnetic Fields Combined with FeO Particles for Killing A375 Melanoma Cells.

机构信息

State Key Laboratory of Power Transmission Equipment Technology, School of Electrical Engineering, Chongqing University, Chongqing 400044, China.

Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing 400030, China.

出版信息

Biomolecules. 2024 Apr 26;14(5):521. doi: 10.3390/biom14050521.

DOI:10.3390/biom14050521
PMID:38785928
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11117552/
Abstract

The combination of magnetic fields and magnetic nanoparticles (MNPs) to kill cancer cells by magneto-mechanical force represents a novel therapy, offering advantages such as non-invasiveness, among others. Pulsed magnetic fields (PMFs) hold promise for application in this therapy due to advantages such as easily adjustable parameters; however, they suffer from the drawback of narrow pulse width. In order to fully exploit the potential of PMFs and MNPs in this therapy, while maximizing therapeutic efficacy within the constraints of the narrow pulse width, a feature-matching theory is proposed, encompassing the matching of three aspects: (1) MNP volume and critical volume of Brownian relaxation, (2) relaxation time and pulse width, and (3) MNP shape and the intermittence of PMF. In the theory, a microsecond-PMF generator was developed, and four kinds of MNPs were selected for in vitro cell experiments. The results demonstrate that the killing rate of the experimental group meeting the requirements of the theory is at least 18% higher than the control group. This validates the accuracy of our theory and provides valuable guidance for the further application of PMFs in this therapy.

摘要

磁场和磁性纳米粒子 (MNPs) 的组合通过磁力学杀死癌细胞代表了一种新的治疗方法，具有非侵入性等优点。脉冲磁场 (PMFs) 由于参数易于调节等优点有望应用于这种治疗，但它们存在脉冲宽度窄的缺点。为了充分利用 PMFs 和 MNPs 在这种治疗中的潜力，同时在窄脉冲宽度的限制内最大限度地提高治疗效果，提出了一种特征匹配理论，包括三个方面的匹配：（1）MNP 体积和布朗松弛的临界体积，（2）弛豫时间和脉冲宽度，以及 (3) MNP 形状和 PMF 的间歇性。在该理论中，开发了一种微秒 PMF 发生器，并选择了四种 MNPs 进行体外细胞实验。结果表明，满足理论要求的实验组的杀伤率至少比对照组高 18%。这验证了我们理论的准确性，并为进一步将 PMFs 应用于这种治疗提供了有价值的指导。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc2/11117552/e55f64491e51/biomolecules-14-00521-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc2/11117552/309e97eb3f13/biomolecules-14-00521-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc2/11117552/068aa8719b7e/biomolecules-14-00521-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc2/11117552/8f589a5d1276/biomolecules-14-00521-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc2/11117552/e78b6add05b4/biomolecules-14-00521-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc2/11117552/384d4c03aba9/biomolecules-14-00521-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc2/11117552/55e326bbc219/biomolecules-14-00521-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc2/11117552/ec565ba442db/biomolecules-14-00521-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc2/11117552/23417113c934/biomolecules-14-00521-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc2/11117552/6f9b1728b383/biomolecules-14-00521-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc2/11117552/8cb0179eb21b/biomolecules-14-00521-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc2/11117552/c6965a5d21e0/biomolecules-14-00521-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc2/11117552/1a1b4ab70dda/biomolecules-14-00521-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc2/11117552/c5036e04dbd6/biomolecules-14-00521-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc2/11117552/e55f64491e51/biomolecules-14-00521-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc2/11117552/309e97eb3f13/biomolecules-14-00521-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc2/11117552/068aa8719b7e/biomolecules-14-00521-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc2/11117552/8f589a5d1276/biomolecules-14-00521-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc2/11117552/e78b6add05b4/biomolecules-14-00521-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc2/11117552/384d4c03aba9/biomolecules-14-00521-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc2/11117552/55e326bbc219/biomolecules-14-00521-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc2/11117552/ec565ba442db/biomolecules-14-00521-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc2/11117552/23417113c934/biomolecules-14-00521-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc2/11117552/6f9b1728b383/biomolecules-14-00521-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc2/11117552/8cb0179eb21b/biomolecules-14-00521-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc2/11117552/c6965a5d21e0/biomolecules-14-00521-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc2/11117552/1a1b4ab70dda/biomolecules-14-00521-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc2/11117552/c5036e04dbd6/biomolecules-14-00521-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc2/11117552/e55f64491e51/biomolecules-14-00521-g014.jpg

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Feature Matching of Microsecond-Pulsed Magnetic Fields Combined with FeO Particles for Killing A375 Melanoma Cells.

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本文引用的文献

[1]
The efficacy of using metformin and/or quercetin for amelioration of gamma-irradiation induced tongue toxicity in diabetic rats.

BMC Oral Health. 2024-1-18

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Zwitterionic Injectable Hydrogel-Combined Chemo- and Immunotherapy Medicated by Monomolecular Micelles to Effectively Prevent the Recurrence of Tumor Post Operation.

ACS Appl Mater Interfaces. 2024-1-24

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Preliminary evaluation of novel Bodily Attention Task to assess the role of the brain in chemotherapy-induced peripheral neurotoxicity (CIPN).

Behav Brain Res. 2024-3-5

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J Phys Chem Lett. 2023-10-12

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Phys Rev E. 2023-3

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Magnetically Induced Brownian Motion of Iron Oxide Nanocages in Alternating Magnetic Fields and Their Application for Efficient siRNA Delivery.

Nano Lett. 2022-11-23

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Nanoscale Adv. 2020-6-19

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