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从罗马尼亚一家县急救医院重症监护病房收治的患者中分离出的ESKAPE组细菌的感染患病率及抗菌药物耐药性

Prevalence of Infections and Antimicrobial Resistance of ESKAPE Group Bacteria Isolated from Patients Admitted to the Intensive Care Unit of a County Emergency Hospital in Romania.

作者信息

Bereanu Alina-Simona, Bereanu Rareș, Mohor Cosmin, Vintilă Bogdan Ioan, Codru Ioana Roxana, Olteanu Ciprian, Sava Mihai

机构信息

Faculty of Medicine, Lucian Blaga University of Sibiu, Lucian Blaga Street 2A, 550169 Sibiu, Romania.

County Clinical Emergency Hospital, Bld. Corneliu Coposu, nr. 2-4, 550245 Sibiu, Romania.

出版信息

Antibiotics (Basel). 2024 Apr 27;13(5):400. doi: 10.3390/antibiotics13050400.

Abstract

UNLABELLED

The ESKAPE group (, , , , , spp.) is a group of bacteria very difficult to treat due to their high ability to acquire resistance to antibiotics and are the main cause of nosocomial infections worldwide, posing a threat to global public health. Nosocomial infections with MDR bacteria are found mainly in Intensive Care Units, due to the multitude of maneuvers and invasive medical devices used, the prolonged antibiotic treatments, the serious general condition of these critical patients, and the prolonged duration of hospitalization.

MATERIALS AND METHODS

During a period of one year, from January 2023 to December 2023, this cross-sectional study was conducted on patients diagnosed with sepsis admitted to the Intensive Care Unit of the Sibiu County Emergency Clinical Hospital. Samples taken were tracheal aspirate, catheter tip, pharyngeal exudate, wound secretion, urine culture, blood culture, and peritoneal fluid.

RESULTS

The most common bacteria isolated from patients admitted to our Intensive Care Unit was , followed by and . Gram-positive cocci ( and ) were rarely isolated. Most of the bacteria isolated were MDR bacteria.

CONCLUSIONS

The rise of antibiotic and antimicrobial resistance among strains in the nosocomial environment and especially in Intensive Care Units raises serious concerns about limited treatment options.

摘要

未标注

ESKAPE菌群(粪肠球菌、金黄色葡萄球菌、肺炎克雷伯菌、鲍曼不动杆菌、铜绿假单胞菌和阴沟肠杆菌)是一组极难治疗的细菌,因为它们极易获得抗生素耐药性,是全球医院感染的主要原因,对全球公共卫生构成威胁。多重耐药菌引起的医院感染主要发生在重症监护病房,原因包括使用大量的操作和侵入性医疗设备、长期使用抗生素治疗、这些重症患者的严重总体状况以及住院时间延长。

材料与方法

在2023年1月至2023年12月的一年时间里,对锡比乌县紧急临床医院重症监护病房收治的脓毒症确诊患者进行了这项横断面研究。采集的样本包括气管吸出物、导管尖端、咽部分泌物、伤口分泌物、尿培养物、血培养物和腹水。

结果

从我们重症监护病房收治的患者中分离出的最常见细菌是肺炎克雷伯菌,其次是鲍曼不动杆菌和铜绿假单胞菌。革兰氏阳性球菌(粪肠球菌和金黄色葡萄球菌)很少分离到。分离出的大多数细菌是多重耐药菌。

结论

医院环境中,尤其是重症监护病房中菌株的抗生素和抗菌药物耐药性增加,引发了对治疗选择有限的严重担忧。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbaf/11117271/df66e4aced78/antibiotics-13-00400-g001.jpg

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