Wang Wenjing, Wang Yadi, Lü Junhong, Li Xueling
Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China.
School of Pharmacy, Binzhou Medical University, Yantai 264003, China.
Gels. 2024 May 9;10(5):324. doi: 10.3390/gels10050324.
Metal-coordinated hydrogels are becoming increasingly popular in the biomedical field due to their unique properties. However, the mechanism behind gel forming involving metal ions is not yet fully understood. In this work, terahertz spectroscopy was used to investigate the role of interfacial water in the gelation process of copper ion-coordinated poly(vinyl alcohol) hydrogels. The results showed that the binding of copper ions could alter the interfacial hydration dynamics of the poly(vinyl alcohol) polymers. Combined with the results of differential scanning calorimetry (DSC), we propose a possible hydration layer-mediated mechanism for the formation of cooper ion-coordinated hydrogel during the freeze-thaw cycle. These results highlight the value of terahertz spectroscopy as a sensor for studying the hydration process in hydrogels and provide an important clue for understanding the mechanism of hydrogelation in ion-coordinated hydrogels.
金属配位水凝胶因其独特的性质在生物医学领域越来越受欢迎。然而，涉及金属离子的凝胶形成背后的机制尚未完全被理解。在这项工作中，太赫兹光谱被用于研究界面水在铜离子配位聚乙烯醇水凝胶凝胶化过程中的作用。结果表明，铜离子的结合可以改变聚乙烯醇聚合物的界面水合动力学。结合差示扫描量热法（DSC）的结果，我们提出了一种在冻融循环过程中形成铜离子配位水凝胶的可能的水合层介导机制。这些结果突出了太赫兹光谱作为研究水凝胶中水合过程的传感器的价值，并为理解离子配位水凝胶的凝胶化机制提供了重要线索。
