Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education, College of Chemistry & Materials Science, Northwest University, 710069, Xi'an, China.
Institut für Chemie und Biochemie, Freie Universität Berlin, Takustrasse 3, 14195, Berlin, Germany.
Angew Chem Int Ed Engl. 2022 May 16;61(21):e202201563. doi: 10.1002/anie.202201563. Epub 2022 Mar 24.
Cobalt (Co ) ions have been an attractive candidate for the biomedical modification of orthopedic implants for decades. However, limited research has been performed into how immobilized Co ions affect the physical properties of implant devices and how these changes regulate cellular behavior. In this study we modified biocompatible poly(vinyl alcohol) with terpyridine and catechol groups (PVA-TP-CA) to create a stable surface coating in which bioactive metal ions could be anchored, endowing the coating with improved broad-spectrum antibacterial activity against Escherichia coli and Staphylococcus aureus, as well as enhanced surface stiffness and cellular mechanoresponse manipulation. Strengthened by the addition of these metal ions, the coating elicited enhanced mechanosensing from adjacent cells, facilitating cell adhesion, spreading, proliferation, and osteogenic differentiation on the surface coating. This dual-functional PVA-TP-CA/Co surface coating offers a promising approach for improving clinical implantation outcomes.
几十年来，钴（Co）离子一直是生物医学修饰骨科植入物的有吸引力的候选物。然而，对于固定化钴离子如何影响植入物设备的物理性质以及这些变化如何调节细胞行为的研究有限。在这项研究中，我们用三吡啶和儿茶酚基团修饰了生物相容性的聚乙烯醇（PVA-TP-CA），以创建一个稳定的表面涂层，其中可以锚定生物活性金属离子，使涂层具有更好的广谱抗菌活性，对大肠杆菌和金黄色葡萄球菌具有抗菌活性，同时提高表面硬度和细胞力学响应的操控能力。通过添加这些金属离子，涂层引起了相邻细胞更强的机械感知，促进了细胞在表面涂层上的黏附、铺展、增殖和成骨分化。这种双重功能的 PVA-TP-CA/Co 表面涂层为改善临床植入物的结果提供了一种很有前途的方法。
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