State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, PR China.
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, PR China.
Carbohydr Polym. 2021 May 15;260:117777. doi: 10.1016/j.carbpol.2021.117777. Epub 2021 Feb 8.
The combination of alginate, hyaluronic acid and multivalent ions have been reported to form alginate-hyaluronic acid ionic-crosslinking hydrogels for biomedical applications. However, injectable alginate-hyaluronic acid ionic-crosslinking hydrogels with satisfactory shear-thinning property have rarely been reported. In this study, we successfully developed an ionic-crosslinked alginate-hyaluronic acid hydrogel by simple assembly of alginate-hyaluronic acid mixture and Fe complex. This hydrogel could fully recover within seconds after damaged, while displayed shear thinning behavior and good injectability which were contributed by the reversible and dynamic metal-ligand interactions formed via ferric ions and carboxyl groups of the polymers. Moreover, the local degradation of this hydrogel giving the hydrogel sustained ferric ions release property, of which led to potential long-term antibacterial activities against multiple types of bacteria including gram-negative Escherichia coli and gram-positive Staphylococcus aureus, as well as representative oral pathogenic bacteria Streptococcus mutans and Porphyromonas gingivalis.
海藻酸盐、透明质酸和多价离子的组合已被报道可形成用于生物医学应用的海藻酸盐-透明质酸离子交联水凝胶。然而，具有令人满意的剪切稀化性能的可注射性海藻酸盐-透明质酸离子交联水凝胶很少有报道。在本研究中，我们通过简单组装海藻酸盐-透明质酸混合物和 Fe 配合物成功开发了一种离子交联的海藻酸盐-透明质酸水凝胶。这种水凝胶在损坏后几秒钟内即可完全恢复，同时表现出剪切稀化行为和良好的可注射性，这归因于通过铁离子和聚合物的羧基形成的可逆和动态金属配体相互作用。此外，该水凝胶的局部降解赋予了水凝胶持续释放铁离子的特性，这使其对包括革兰氏阴性大肠杆菌和革兰氏阳性金黄色葡萄球菌在内的多种类型细菌以及代表性口腔致病菌变形链球菌和牙龈卟啉单胞菌具有潜在的长期抗菌活性。
