School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei 110301, Taiwan.
Department of Nursing, Deh Yu College of Nursing and Health, Keelung 203301, Taiwan.
Mar Drugs. 2024 May 6;22(5):211. doi: 10.3390/md22050211.
Osteoarthritis (OA) is a debilitating joint disorder characterized by cartilage degradation and chronic inflammation, accompanied by high oxidative stress. In this study, we utilized the monosodium iodoacetate (MIA)-induced OA model to investigate the efficacy of oligo-fucoidan-based formula (FF) intervention in mitigating OA progression. Through its capacity to alleviate joint bearing function and inflammation, improvements in cartilage integrity following oligo-fucoidan-based formula intervention were observed, highlighting its protective effects against cartilage degeneration and structural damage. Furthermore, the oligo-fucoidan-based formula modulated the p38 signaling pathway, along with downregulating cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression, contributing to its beneficial effects. Our study provides valuable insights into targeted interventions for OA management and calls for further clinical investigations to validate these preclinical findings and to explore the translational potential of an oligo-fucoidan-based formula in human OA patients.
骨关节炎（OA）是一种使人衰弱的关节疾病，其特征是软骨退化和慢性炎症，伴有高氧化应激。在这项研究中，我们利用碘酸钠（MIA）诱导的 OA 模型来研究寡聚岩藻多糖基配方（FF）干预减轻 OA 进展的功效。通过减轻关节承重功能和炎症，观察到寡聚岩藻多糖基配方干预后软骨完整性的改善，突出了其对软骨退化和结构损伤的保护作用。此外，寡聚岩藻多糖基配方调节了 p38 信号通路，同时下调环氧化酶-2（COX-2）和诱导型一氧化氮合酶（iNOS）的表达，对其有益作用有贡献。我们的研究为 OA 管理的靶向干预提供了有价值的见解，并呼吁进一步的临床研究来验证这些临床前发现，并探索寡聚岩藻多糖基配方在人类 OA 患者中的转化潜力。
