Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang of Jiangxi, China.
Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang of Jiangxi, China.
Nutr Metab Cardiovasc Dis. 2023 Apr;33(4):809-816. doi: 10.1016/j.numecd.2023.01.020. Epub 2023 Jan 29.
A relationship exists between dietary copper intake and hypertriglyceridemia in the United States (US). However, children and adolescents have there is limited research data for children and adolescents, who have not been thoroughly investigated. This study aimed to carefully evaluate this relationship.
This cross-sectional study included 3982 children and adolescents who participated in the US National Health and Nutrition Examination Survey 1999-2006. The outcome variable was hypertriglyceridemia, defined as a triglyceride (TG) concentration >150 mg/dL. Multivariate and binary logistic regression models were applied in this study. The median (Q1-Q3) copper intake and TG levels were 0.98 (0.71-1.32) mg/d and 72.00 (53.00-100.00) mg/dL, respectively. The smoothing curve showed an inverted L-shaped relationship between copper intake and the prevalence of hypertriglyceridemia in American children and adolescents. A binary logistic regression model was developed to evaluate the relationship between copper intake and the prevalence of hypertriglyceridemia, and the inflection point was 0.76 mg/d. The odds of developing hypertriglyceridemia significantly increased with increasing levels of copper intake (odds ratio (OR), 2.00; 95% confidence interval (CI): 1.39-2.86) in participants with copper intake >0.76 mg/d (P for log likelihood ratio test = 0.032). The association between high copper intake and increased hypertriglyceridemia risk was significantly stronger in participants with a high body mass index (BMI; ≥23 kg/m) (OR: 2.09; 95% CI: 1.42-3.07) than in those with a low BMI (tertile 1-2) (p for interaction = 0.048). Moreover, the increase in copper intake in adolescents aged 13-18 years significantly increased the prevalence of hypertriglyceridemia (OR: 1.95; 95% CI: 1.38-2.76; p for interaction = 0.001).
Higher dietary copper intake increases the prevalence of hypertriglyceridemia, especially among US adolescents with a BMI ≥23 kg/m.
在美国，膳食铜摄入量与高甘油三酯血症之间存在一定关系。然而，针对儿童和青少年的相关研究数据有限，且这一人群并未得到充分的研究。本研究旨在对此关系进行详细评估。
本横断面研究纳入了 3982 名参与了 1999-2006 年美国国家健康和营养调查的儿童和青少年。结局变量为高甘油三酯血症，定义为甘油三酯（TG）浓度>150mg/dL。本研究采用了多变量和二元逻辑回归模型。铜摄入量和 TG 水平的中位数（Q1-Q3）分别为 0.98（0.71-1.32）mg/d 和 72.00（53.00-100.00）mg/dL。平滑曲线显示，美国儿童和青少年的铜摄入量与高甘油三酯血症的患病率之间存在倒 L 形关系。建立了二元逻辑回归模型来评估铜摄入量与高甘油三酯血症患病率之间的关系，拐点为 0.76mg/d。在铜摄入量>0.76mg/d 的参与者中，随着铜摄入量的增加，高甘油三酯血症的发病风险显著增加（比值比（OR）2.00；95%置信区间（CI）：1.39-2.86）（P 对数似然比检验=0.032）。在 BMI（≥23kg/m2）较高的参与者中（OR：2.09；95%CI：1.42-3.07），高铜摄入与高甘油三酯血症风险增加之间的关联明显强于 BMI（第 1-2 三分位数）较低的参与者（交互作用检验 P=0.048）。此外，13-18 岁青少年铜摄入量的增加显著增加了高甘油三酯血症的患病率（OR：1.95；95%CI：1.38-2.76；交互作用检验 P=0.001）。
较高的膳食铜摄入量会增加高甘油三酯血症的患病率，尤其是在美国 BMI（≥23kg/m2）较高的青少年中。
