Eisenberg R A, Riblet R J, Lewis D E, Cohen P L
Clin Exp Immunol. 1985 Nov;62(2):315-20.
We have further investigated the phenomenon of spontaneous anti-(Coombs) antiidiotypic antibodies in the F1 hybrids of New Zealand black (NZB) and CBA mice. These mice show an age-related increase in incidence of such antiidiotype during the first year of life. There is no difference between males and females in the occurrence of antiidiotype. Reciprocal hybrids are both affected, so that maternal influence from the NZB strain is not critical. The antiidiotype also occurs in spite of the xid gene. We have so far detected such spontaneous antiidiotype only in (CBA X NZB)F1 hybrids and not in hybrids of NZB with two other strains or in a variety of recombinant inbred strains between NZB and C58. Our results to data suggest extensive shared idiotypy among NZB mice and a limited number of total idiotypes.
我们进一步研究了新西兰黑鼠（NZB）与CBA小鼠的F1代杂种中自发抗（库姆斯）抗独特型抗体的现象。这些小鼠在出生后的第一年中，此类抗独特型抗体的发生率呈现与年龄相关的增长。抗独特型抗体的出现不存在性别差异。正反交杂种均受影响，因此NZB品系的母体影响并不关键。即使存在xid基因，抗独特型抗体依然会出现。到目前为止，我们仅在（CBA×NZB）F1代杂种中检测到这种自发抗独特型抗体，而在NZB与其他两个品系的杂种中，以及在NZB和C58之间的各种重组近交系中均未检测到。我们目前的结果表明，NZB小鼠之间存在广泛的共享独特型，且总的独特型数量有限。
