Department of Hybrid Biofunctional Materials, CIC biomaGUNE, Basque Research and Technology Alliance (BRTA), Paseo de Miramon 194, 20014 Donostia-San Sebastián, Spain.
Group of Bioengineering in Regeneration and Cancer, Biogipuzkoa Health Research Institute, 20014 Donostia-San Sebastián, Spain.
Nanoscale. 2024 Jun 13;16(23):10880-10900. doi: 10.1039/d3nr06672j.
Being a vital organ exposed to the external environment, the lung is susceptible to a plethora of pathogens and pollutants. This is reflected in high incidences of chronic respiratory diseases, which remain a leading cause of mortality world-wide and pose a persistent global burden. It is thus of paramount importance to improve our understanding of these pathologies and provide better therapeutic options. This necessitates the development of representative and physiologically relevant models. Advances in bioengineering have enabled the development of sophisticated models that not only capture the three-dimensional architecture of the cellular environment but also incorporate the dynamics of local biophysical stimuli. However, such complex models also require novel approaches that provide reliable characterization. Within this review we explore how 3D bioprinting and nanoparticles can serve as multifaceted tools to develop such dynamic 4D printed lung models and facilitate their characterization in the context of pulmonary fibrosis and breast cancer lung metastasis.
作为一个暴露于外部环境的重要器官，肺部容易受到多种病原体和污染物的影响。这反映在慢性呼吸道疾病的高发率上，这些疾病仍然是全球范围内的主要死亡原因，并构成持续的全球负担。因此，提高我们对这些疾病的认识并提供更好的治疗选择至关重要。这需要开发具有代表性和生理相关性的模型。生物工程的进步使开发复杂模型成为可能，这些模型不仅可以捕捉细胞环境的三维结构，还可以纳入局部生物物理刺激的动态。然而，这种复杂的模型也需要新的方法来提供可靠的特征描述。在这篇综述中，我们探讨了 3D 生物打印和纳米颗粒如何作为多方面的工具来开发这种动态 4D 打印的肺模型，并促进它们在肺纤维化和乳腺癌肺转移背景下的特征描述。
