Department of Ophthalmology, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China; Hunan Clinical Research Center of Ophthalmic Disease, Changsha, Hunan, China.
Department of Ophthalmology, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China; Hunan Clinical Research Center of Ophthalmic Disease, Changsha, Hunan, China.
Biochem Pharmacol. 2024 Jul;225:116311. doi: 10.1016/j.bcp.2024.116311. Epub 2024 May 22.
Diabetic retinopathy (DR) is a severe ocular complication of diabetes which can leads to irreversible vision loss in its late-stage. Chronic inflammation results from long-term hyperglycemia contributes to the pathogenesis and progression of DR. In recent years, the interleukin-17 (IL-17) family have attracted the interest of researchers. IL-17A is the most widely explored cytokine in IL-17 family, involved in various acute and chronic inflammatory diseases. Growing body of evidence indicate the role of IL-17A in the pathogenesis of DR. However, the pro-inflammatory and pro-angiogenic effect of IL-17A in DR have not hitherto been reviewed. Gaining an understanding of the pro-inflammatory role of IL-17A, and how IL-17A control/impact angiogenesis pathways in the eye will deepen our understanding of how IL-17A contributes to DR pathogenesis. Herein, we aimed to thoroughly review the pro-inflammatory role of IL-17A in DR, with focus in how IL-17A impact inflammation and angiogenesis crosstalk.
糖尿病视网膜病变（DR）是糖尿病的一种严重眼部并发症，其晚期可导致不可逆转的视力丧失。长期高血糖引起的慢性炎症是 DR 发病机制和进展的原因。近年来，白细胞介素-17（IL-17）家族引起了研究人员的兴趣。IL-17A 是 IL-17 家族中研究最广泛的细胞因子，涉及各种急性和慢性炎症性疾病。越来越多的证据表明 IL-17A 在 DR 的发病机制中起作用。然而，IL-17A 在 DR 中的促炎和促血管生成作用尚未得到综述。深入了解 IL-17A 的促炎作用，以及 IL-17A 如何控制/影响眼部的血管生成途径，将加深我们对 IL-17A 如何促进 DR 发病机制的理解。在此，我们旨在全面综述 IL-17A 在 DR 中的促炎作用，重点关注 IL-17A 如何影响炎症和血管生成的相互作用。
