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在眼科门诊管理特发性颅内高压。

Managing idiopathic intracranial hypertension in the eye clinic.

机构信息

Department of Ophthalmology, University of California, Los Angeles, Stein Eye Institute, Los Angeles, CA, USA.

Birmingham Neuro-Ophthalmology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, B15 2GW, UK.

出版信息

Eye (Lond). 2024 Aug;38(12):2472-2481. doi: 10.1038/s41433-024-03140-y. Epub 2024 May 24.

Abstract

Idiopathic intracranial hypertension (IIH) is a neuro-ophthalmological condition characterised by a raised intracranial pressure and papilloedema that causes disabling headaches. The main risk factors of female sex and living with obesity have been known for some time, however the knowledge of the underlying pathophysiology is evolving. Papilloedema can impact the visual function, and the majority of people are offered acetazolamide. Those with sight threatening disease need urgent management, though there is little high quality evidence to recommend any particular surgical intervention. Headache treatment is an unmet clinical need and simple medication overuse advice has the potential to reduce the chronification of migraine-like headaches. IIH is emerging as a systemic metabolic disease distinct from people living with obesity alone. While weight loss is the main stay of disease modifying therapy this is challenging to access and many healthcare professionals that manage the condition have no formal training or accessible pathways for weight management. The aim of this "how to do it" article is to present the latest advances in knowledge of IIH that we pragmatically included in routine clinical care for people living with the condition.

摘要

特发性颅内高压(IIH)是一种神经眼科疾病,其特征是颅内压升高和视乳头水肿,导致致残性头痛。女性和肥胖是该病的主要危险因素,这一点早已为人所知,但该病潜在病理生理学的相关知识仍在不断发展。视乳头水肿会影响视力功能,大多数人会接受乙酰唑胺治疗。对于有威胁视力的疾病患者需要紧急治疗,但几乎没有高质量的证据推荐任何特定的手术干预。头痛治疗是一个未满足的临床需求,简单的药物滥用咨询有可能减少偏头痛样头痛的慢性化。IIH 正在成为一种与肥胖人群不同的系统性代谢疾病。虽然减肥是疾病修正治疗的主要方法,但这很难实现,许多管理该病的医疗保健专业人员没有接受过正式的体重管理培训或途径。本文旨在介绍 IIH 最新的知识进展,这些知识已被我们实际纳入到对该病患者的常规临床护理中。

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