Pan Xiongfeng, Tan Xinrui, McDonald Judy, Kaminga Atipatsa Chiwanda, Chen Yuyao, Dai Feizhao, Qiu Jun, Zhao Kunyan, Peng Yunlong
Pediatrics Research Institute of Hunan Province, Hunan Children's Hospital, 86 Ziyuan Rd, Changsha, Hunan, People's Republic of China, 410007.
The Affiliated Children's Hospital of Xiangya School of Medicine, Central South University, Changsha, China.
Diabetol Metab Syndr. 2024 May 24;16(1):115. doi: 10.1186/s13098-024-01297-w.
Diabetic eye disease is a common micro-vascular complication of diabetes and a leading cause of decreased vision and blindness in people of working age worldwide.Although previous studies have shown that chemokines system may be a player in pathogenesis of diabetic eye disease, it is unclear which chemokines play the most important role.To date, there is no meta-analysis which has investigated the role of chemokines in diabetic eye disease.We hope this study will contribute to a better understanding of both the signaling pathways of the chemokines in the pathophysiological process, and more reliable therapeutic targets for diabetic eye disease.
Embase, PubMed, Web of Science and Cochrane Library systematically searched for relevant studies from inception to Sep 1, 2023. A random-effect model was used and standardized mean differences (SMDs) and 95% confidence intervals (CIs) were calculated to summarize the associated measure between chemokines concentrations and diabetic eye disease. Network meta-analysis to rank chemokines-effect values according to ranked probabilities.
A total of 33 different chemokines involving 11,465 subjects (6559 cases and 4906 controls) were included in the meta-analysis. Results of the meta-analysis showed that concentrations of CC and CXC chemokines in the diabetic eye disease patients were significantly higher than those in the controls. Moreover, network meta-analysis showed that the effect of CCL8, CCL2, CXCL8 and CXCL10 were ranked highest in terms of probabilities. Concentrations of CCL8, CCL2, CXCL8 and CXCL10 may be associated with diabetic eye disease, especially in diabetic retinopathy and diabetic macular edema.
Our study suggests that CCL2 and CXCL8 may play key roles in pathogenesis of diabetic eye disease. Future research should explore putative mechanisms underlying these links, with the commitment to develop novel prophylactic and therapeutic for diabetic eye disease.
糖尿病眼病是糖尿病常见的微血管并发症，也是全球劳动年龄人群视力下降和失明的主要原因。尽管先前的研究表明趋化因子系统可能参与糖尿病眼病的发病机制，但尚不清楚哪些趋化因子起最重要作用。迄今为止，尚无荟萃分析研究趋化因子在糖尿病眼病中的作用。我们希望这项研究将有助于更好地理解趋化因子在病理生理过程中的信号通路，以及为糖尿病眼病找到更可靠的治疗靶点。
通过Embase、PubMed、Web of Science和Cochrane图书馆系统检索从创刊到2023年9月1日的相关研究。采用随机效应模型，计算标准化均数差（SMD）和95%置信区间（CI），以总结趋化因子浓度与糖尿病眼病之间的相关测量值。进行网络荟萃分析，根据排序概率对趋化因子效应值进行排序。
荟萃分析共纳入33种不同趋化因子，涉及11465名受试者（6559例病例和4906例对照）。荟萃分析结果显示，糖尿病眼病患者中CC和CXC趋化因子的浓度显著高于对照组。此外，网络荟萃分析显示，CCL8、CCL2、CXCL8和CXCL10的效应在概率方面排名最高。CCL8、CCL2、CXCL8和CXCL10的浓度可能与糖尿病眼病有关，尤其是在糖尿病视网膜病变和糖尿病黄斑水肿中。
我们的研究表明CCL2和CXCL8可能在糖尿病眼病的发病机制中起关键作用。未来的研究应探索这些联系背后的潜在机制，致力于开发针对糖尿病眼病的新型预防和治疗方法。
