Geltman E M
West J Med. 1985 Dec;143(6):764-72.
Positron emission tomography (PET) is a new technique for noninvasively assessing myocardial metabolism and perfusion. It has provided new insight into the dynamics of myocardial fatty acid and glucose metabolism in normal subjects, patients with ischemic heart disease and those with cardiomyopathies, documenting regionally depressed fatty acid metabolism during myocardial ischemia and infarction and spatial heterogeneity of fatty acid metabolism in patients with cardiomyopathy. Regional myocardial perfusion has been studied with PET using water, ammonia and rubidium labeled with positron emitters, permitting the noninvasive detection of hypoperfused zones at rest and during vasodilator stress. With these techniques the relationship between perfusion and the metabolism of a variety of substrates has been studied. The great strides that have been made in developing faster high-resolution instruments and producing new labeled intermediates indicate the promise of this technique for facilitating an increase in the understanding of regional metabolism and blood flow under normal and pathophysiologic conditions.
正电子发射断层扫描（PET）是一种用于无创评估心肌代谢和灌注的新技术。它为正常受试者、缺血性心脏病患者和心肌病患者的心肌脂肪酸和葡萄糖代谢动态提供了新的见解，记录了心肌缺血和梗死期间局部脂肪酸代谢降低以及心肌病患者脂肪酸代谢的空间异质性。使用正电子发射体标记的水、氨和铷，通过PET对局部心肌灌注进行了研究，从而能够无创检测静息状态和血管扩张应激期间的灌注不足区域。利用这些技术，研究了灌注与多种底物代谢之间的关系。在开发更快的高分辨率仪器和生产新的标记中间体方面取得的巨大进展表明，这项技术有望促进人们对正常和病理生理条件下局部代谢和血流的理解。
