• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

柠檬酸酯化淀粉和酶法脱支淀粉的特性及其对糖尿病小鼠的影响。

Characteristics of Citrate-Esterified Starch and Enzymatically Debranched Starch and Their Effects on Diabetic Mice.

作者信息

Wang Nannan, Ding Changhe, Xie Yingying, Meng Jun, Fan Xing, Fan Duoduo, Wan Haowei, Jiang Zhengqiang

机构信息

College of Food Science and Engineering, Henan University of Technology, Zhengzhou 450001, China.

Food Laboratory of Zhongyuan, Luohe 462300, China.

出版信息

Foods. 2024 May 10;13(10):1486. doi: 10.3390/foods13101486.

DOI:10.3390/foods13101486
PMID:38790786
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11120290/
Abstract

Chickpea has significant benefits as an adjuvant treatment for type 2 diabetes mellitus (T2DM). The properties of chickpea resistant starches (RSs) and their abilities to reduce T2DM symptoms and control intestinal flora were investigated. The RS content in citrate-esterified starch (CCS; 74.18%) was greater than that in pullulanase-modified starch (enzymatically debranched starch (EDS); 38.87%). Compared with those of native chickpea starch, there were noticeable changes in the granular structure and morphology of the two modified starches. The CCS showed surface cracking and aggregation. The EDS particles exhibited irregular layered structures. The expansion force of the modified starches decreased. The CCS and EDS could successfully lower blood glucose, regulate lipid metabolism, lower the levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C), reduce the expressions of interleukin-6 (IL-6) and interleuki n-10 (IL-10), and decrease diabetes-related liver damage. Moreover, the CCS and EDS altered the intestinal flora makeup in mice with T2DM. The abundance of Bacteroidota increased. Both types of chickpea RSs exhibited significant hypoglycaemic and hypolipidaemic effects, contributing to the reduction in inflammatory levels and the improvement in gut microbiota balance.

摘要

鹰嘴豆作为2型糖尿病（T2DM）的辅助治疗具有显著益处。研究了鹰嘴豆抗性淀粉（RSs）的特性及其减轻T2DM症状和控制肠道菌群的能力。柠檬酸酯化淀粉（CCS；74.18%）中的RS含量高于支链淀粉酶改性淀粉（酶法脱支淀粉（EDS）；38.87%）。与天然鹰嘴豆淀粉相比，两种改性淀粉的颗粒结构和形态有明显变化。CCS出现表面开裂和聚集。EDS颗粒呈现不规则的层状结构。改性淀粉的膨胀力降低。CCS和EDS可成功降低血糖、调节脂质代谢、降低总胆固醇（TC）和低密度脂蛋白胆固醇（LDL-C）水平、降低白细胞介素-6（IL-6）和白细胞介素-10（IL-10）的表达，并减轻糖尿病相关的肝损伤。此外，CCS和EDS改变了T2DM小鼠的肠道菌群组成。拟杆菌门的丰度增加。两种类型的鹰嘴豆RSs均表现出显著的降血糖和降血脂作用，有助于降低炎症水平和改善肠道微生物群平衡。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/656f/11120290/5ef5f514fcf9/foods-13-01486-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/656f/11120290/331ded471dab/foods-13-01486-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/656f/11120290/4efc70b99b21/foods-13-01486-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/656f/11120290/b487c5793052/foods-13-01486-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/656f/11120290/0226219d4fd5/foods-13-01486-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/656f/11120290/4dbb15c287f0/foods-13-01486-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/656f/11120290/d91d3580ce7f/foods-13-01486-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/656f/11120290/ba40f0399bfd/foods-13-01486-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/656f/11120290/baabc8dabc28/foods-13-01486-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/656f/11120290/7280861c2062/foods-13-01486-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/656f/11120290/cfaa9b44b8f0/foods-13-01486-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/656f/11120290/1e9437f69d0a/foods-13-01486-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/656f/11120290/4a09d24b8e46/foods-13-01486-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/656f/11120290/5673135f4a15/foods-13-01486-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/656f/11120290/ee387222c342/foods-13-01486-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/656f/11120290/7df8860b045e/foods-13-01486-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/656f/11120290/fdb7a3ea6e74/foods-13-01486-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/656f/11120290/5ef5f514fcf9/foods-13-01486-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/656f/11120290/331ded471dab/foods-13-01486-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/656f/11120290/4efc70b99b21/foods-13-01486-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/656f/11120290/b487c5793052/foods-13-01486-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/656f/11120290/0226219d4fd5/foods-13-01486-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/656f/11120290/4dbb15c287f0/foods-13-01486-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/656f/11120290/d91d3580ce7f/foods-13-01486-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/656f/11120290/ba40f0399bfd/foods-13-01486-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/656f/11120290/baabc8dabc28/foods-13-01486-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/656f/11120290/7280861c2062/foods-13-01486-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/656f/11120290/cfaa9b44b8f0/foods-13-01486-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/656f/11120290/1e9437f69d0a/foods-13-01486-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/656f/11120290/4a09d24b8e46/foods-13-01486-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/656f/11120290/5673135f4a15/foods-13-01486-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/656f/11120290/ee387222c342/foods-13-01486-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/656f/11120290/7df8860b045e/foods-13-01486-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/656f/11120290/fdb7a3ea6e74/foods-13-01486-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/656f/11120290/5ef5f514fcf9/foods-13-01486-g017.jpg

相似文献

1
Characteristics of Citrate-Esterified Starch and Enzymatically Debranched Starch and Their Effects on Diabetic Mice.柠檬酸酯化淀粉和酶法脱支淀粉的特性及其对糖尿病小鼠的影响。
Foods. 2024 May 10;13(10):1486. doi: 10.3390/foods13101486.
2
Structural changes and digestibility of waxy maize starch debranched by different levels of pullulanase.不同水平普鲁兰酶对蜡质玉米淀粉解支后的结构变化及消化性。
Carbohydr Polym. 2018 Aug 15;194:350-356. doi: 10.1016/j.carbpol.2018.04.053. Epub 2018 Apr 13.
3
Effects of microwave treatments and retrogradation on molecular crystalline structure and in vitro digestibility of debranched mung-bean starches.微波处理和回生对支链绿豆淀粉的分子结晶结构和体外消化率的影响。
Int J Biol Macromol. 2021 Nov 1;190:904-910. doi: 10.1016/j.ijbiomac.2021.09.032. Epub 2021 Sep 14.
4
Preparation of type 3 rice resistant starch using high-pressure homogenous coenzyme treatment and investigating its potential therapeutic effects on blood glucose and intestinal flora in db/db mice.利用高压均相辅酶处理制备 3 型大米抗性淀粉及其对 db/db 小鼠血糖和肠道菌群的潜在治疗作用研究。
Int J Biol Macromol. 2024 Apr;264(Pt 2):130552. doi: 10.1016/j.ijbiomac.2024.130552. Epub 2024 Mar 3.
5
Anti-hyperlipidemic and ameliorative effects of chickpea starch and resistant starch in mice with high fat diet induced obesity are associated with their multi-scale structural characteristics.鹰嘴豆淀粉和抗性淀粉通过多尺度结构特性对高脂肪饮食诱导肥胖小鼠的降脂及改善作用。
Food Funct. 2022 May 10;13(9):5135-5152. doi: 10.1039/d1fo04354d.
6
Isolated Pea Resistant Starch Substrates with Different Structural Features Modulate the Production of Short-Chain Fatty Acids and Metabolism of Microbiota in Anaerobic Fermentation In Vitro.具有不同结构特征的豌豆抗性淀粉底物可调节体外厌氧发酵中短链脂肪酸的产生和微生物群落的代谢。
J Agric Food Chem. 2021 May 12;69(18):5392-5404. doi: 10.1021/acs.jafc.0c08197. Epub 2021 Apr 12.
7
Physico-chemical properties and digestibility of native and citrate starches change in different ways by synchrotron radiation.天然淀粉和柠檬酸淀粉的物理化学性质及消化率在同步辐射下会以不同方式发生变化。
Int J Biol Macromol. 2022 May 15;207:475-483. doi: 10.1016/j.ijbiomac.2022.03.033. Epub 2022 Mar 9.
8
Effect of triple retrogradation treatment on chickpea resistant starch formation and its characterization.三重回生处理对鹰嘴豆抗性淀粉形成及其特性的影响。
J Food Sci Technol. 2017 Mar;54(4):901-908. doi: 10.1007/s13197-016-2308-7. Epub 2016 Aug 24.
9
Kudzu Resistant Starch: An Effective Regulator of Type 2 Diabetes Mellitus.葛根抗性淀粉：一种有效的 2 型糖尿病调节剂。
Oxid Med Cell Longev. 2021 Oct 13;2021:4448048. doi: 10.1155/2021/4448048. eCollection 2021.
10
Pullulanase treatments to increase resistant starch content of black chickpea (Cicer arietinum L.) starch and the effects on starch properties.普鲁兰酶处理提高黑鹰嘴豆（Cicer arietinum L.）淀粉的抗性淀粉含量及其对淀粉性质的影响。
Int J Biol Macromol. 2018 May;111:505-513. doi: 10.1016/j.ijbiomac.2018.01.026. Epub 2018 Jan 7.

引用本文的文献

1
Effect of fermentation on the constituents in the branches and leaves of and non-small cell lung cancer.发酵对[具体植物名称未给出]枝叶成分及非小细胞肺癌的影响 。
Front Pharmacol. 2024 Oct 23;15:1449498. doi: 10.3389/fphar.2024.1449498. eCollection 2024.

本文引用的文献

1
The Molecular Mechanism Underlying the Therapeutic Effect of Dihydromyricetin on Type 2 Diabetes Mellitus Based on Network Pharmacology, Molecular Docking, and Transcriptomics.基于网络药理学、分子对接和转录组学探究二氢杨梅素治疗2型糖尿病的分子机制
Foods. 2024 Jan 22;13(2):344. doi: 10.3390/foods13020344.
2
Broccoli Improves Lipid Metabolism and Intestinal Flora in Mice with Type 2 Diabetes Induced by HFD and STZ Diet.西兰花改善高脂高糖饮食和链脲佐菌素诱导的2型糖尿病小鼠的脂质代谢及肠道菌群。
Foods. 2024 Jan 15;13(2):273. doi: 10.3390/foods13020273.
3
The Effect of Acetylation on the Physicochemical Properties of Chickpea Starch.
乙酰化对鹰嘴豆淀粉理化性质的影响。
Foods. 2023 Jun 23;12(13):2462. doi: 10.3390/foods12132462.
4
The research advance of resistant starch: structural characteristics, modification method, immunomodulatory function, and its delivery systems application.抗性淀粉的研究进展：结构特性、修饰方法、免疫调节功能及其传递系统的应用。
Crit Rev Food Sci Nutr. 2024;64(29):10885-10902. doi: 10.1080/10408398.2023.2230287. Epub 2023 Jul 6.
5
Insights into ultrasound-induced starch-lipid complexes to understand physicochemical and nutritional interventions.超声诱导淀粉-脂质复合物的研究进展：理解物理化学和营养干预。
Int J Biol Macromol. 2022 Dec 1;222(Pt A):950-960. doi: 10.1016/j.ijbiomac.2022.09.242. Epub 2022 Sep 29.
6
The association between blood glucose levels and lipids or lipid ratios in type 2 diabetes patients: A cross-sectional study.2 型糖尿病患者血糖水平与血脂或血脂比值的相关性：一项横断面研究。
Front Endocrinol (Lausanne). 2022 Sep 6;13:969080. doi: 10.3389/fendo.2022.969080. eCollection 2022.
7
Anti-hyperlipidemic and ameliorative effects of chickpea starch and resistant starch in mice with high fat diet induced obesity are associated with their multi-scale structural characteristics.鹰嘴豆淀粉和抗性淀粉通过多尺度结构特性对高脂肪饮食诱导肥胖小鼠的降脂及改善作用。
Food Funct. 2022 May 10;13(9):5135-5152. doi: 10.1039/d1fo04354d.
8
A Novel PTP1B Inhibitor-Phosphate of Polymannuronic Acid Ameliorates Insulin Resistance by Regulating IRS-1/Akt Signaling.新型 PTP1B 抑制剂——多聚甘露糖醛酸磷酸酯通过调节 IRS-1/Akt 信号通路改善胰岛素抵抗。
Int J Mol Sci. 2021 Nov 24;22(23):12693. doi: 10.3390/ijms222312693.
9
Kudzu Resistant Starch: An Effective Regulator of Type 2 Diabetes Mellitus.葛根抗性淀粉：一种有效的 2 型糖尿病调节剂。
Oxid Med Cell Longev. 2021 Oct 13;2021:4448048. doi: 10.1155/2021/4448048. eCollection 2021.
10
LC89 exerts antidiabetic effects through regulating hepatic glucagon response and gut microbiota in type 2 diabetic mice.LC89 通过调节 2 型糖尿病小鼠的肝胰高血糖素反应和肠道微生物群发挥抗糖尿病作用。
Food Funct. 2021 Sep 20;12(18):8288-8299. doi: 10.1039/d1fo00882j.