Moshomo Thato, Molefe-Baikai Onkabetse Julia, Bennett Kara, Gaolathe Tendani, Moyo Sikhulile, Gaseitsewe Simani, Mohammed Terence, Lockman Shahin, Mosepele Mosepele
Department of Internal Medicine, Faculty of Medicine, University of Botswana, Gaborone Private Bag 00713, Botswana.
Bennett Statistical Consulting, Inc., Ballston Lake, NY 12019, USA.
Biomedicines. 2024 Apr 23;12(5):935. doi: 10.3390/biomedicines12050935.
Cytomegalovirus (CMV) has been linked with increased cardiovascular risk and monocyte activation in people living with HIV (PLWH). This cross-sectional study aimed to compare CMV immunoglobulin G (IgG) levels between combined antiretroviral therapy (cART)-treated PLWH versus ART-naïve PLWH and those without HIV, and to investigate their associations with biomarkers of endothelial injury and carotid atherosclerosis, in Gaborone, Botswana. All participants were between 30 and 50 years old. Carotid intimal media thickness (cIMT) and biomarkers of endothelial injury and monocyte activation were also assessed. The association between quantitative CMV IgG and cardiovascular disease risk was assessed in multivariate logistic regression analysis. The results showed that the mean CMV IgG level among ART-naïve participants was significantly higher than both the cART group and controls. However, CMV IgG levels did not differ significantly between the controls and cART groups. Among PLWH, CMV IgG levels were associated with ICAM-1 levels and cIMT. Increases in CMV IgG among ART-naïve participants were significantly associated with increases in log VCAM-1. In conclusion, CMV IgG levels are elevated among PLWH in sub-Saharan Africa, and higher levels are associated with biomarkers of endothelial injury and cIMT. Future research should investigate the long-term impact of elevated CMV IgG among PLWH.
巨细胞病毒（CMV）与人类免疫缺陷病毒感染者（PLWH）心血管疾病风险增加及单核细胞活化有关。这项横断面研究旨在比较接受联合抗逆转录病毒疗法（cART）的PLWH、未接受抗逆转录病毒治疗的PLWH以及未感染HIV者之间的CMV免疫球蛋白G（IgG）水平，并在博茨瓦纳哈博罗内调查其与内皮损伤生物标志物和颈动脉粥样硬化的关联。所有参与者年龄在30至50岁之间。还评估了颈动脉内膜中层厚度（cIMT）以及内皮损伤和单核细胞活化的生物标志物。在多变量逻辑回归分析中评估了定量CMV IgG与心血管疾病风险之间的关联。结果显示，未接受抗逆转录病毒治疗的参与者中CMV IgG的平均水平显著高于接受cART治疗的组和对照组。然而，对照组和接受cART治疗的组之间CMV IgG水平没有显著差异。在PLWH中，CMV IgG水平与细胞间黏附分子-1（ICAM-1）水平和cIMT有关。未接受抗逆转录病毒治疗的参与者中CMV IgG的增加与血管细胞黏附分子-1（VCAM-1）对数的增加显著相关。总之，撒哈拉以南非洲的PLWH中CMV IgG水平升高，较高水平与内皮损伤生物标志物和cIMT有关。未来的研究应调查PLWH中CMV IgG升高的长期影响。
