Weippl G, Michos N, Stocker H
Arzneimittelforschung. 1985;35(11):1732-4.
In a study including a total of 175 children, ranging in age from 3 months to 3 years and suffering from otitis media, the analgesic effect of alpha-methyl-4-(2-thienylcarbonyl)-phenyl acetic acid (suprofen, Suprol) syrup was compared with that of lidocaine 0.03 g/6 g + phenazone (phenyl-dimethylpyrazolone) 0.03 g/6 g (L PDP) ear drops. The study was designed as an open controlled trial. The test medications were applied in single doses: suprofen 5-7.5 mg/kg b.w., orally; (L PDP) 1 drop, locally. The severity of pain was assessed in the beginning of the treatment and 2 h following administration of the drugs. The results were indicative of the fact that in children on suprofen syrup marked pain relief was obtained, whereas the painful condition of children on L PDP ear drops even deteriorated.
在一项总共纳入175名年龄在3个月至3岁之间且患有中耳炎的儿童的研究中，比较了α-甲基-4-(2-噻吩羰基)-苯乙酸（舒洛芬，Suprol）糖浆与0.03 g/6 g利多卡因+0.03 g/6 g非那宗（苯基二甲基吡唑啉酮）（L PDP）耳滴剂的镇痛效果。该研究设计为开放性对照试验。试验药物采用单剂量给药：舒洛芬5 - 7.5 mg/kg体重，口服；（L PDP）1滴，局部用药。在治疗开始时以及给药后2小时评估疼痛的严重程度。结果表明，服用舒洛芬糖浆的儿童疼痛明显缓解，而使用L PDP耳滴剂的儿童疼痛状况甚至恶化。
