Department of Chemistry, University of Fort Hare, Alice 5700, South Africa.
Molecules. 2024 May 12;29(10):2277. doi: 10.3390/molecules29102277.
Cancer is ranked among lethal diseases globally, and the increasing number of cancer cases and deaths results from limited access to effective therapeutics. The use of plant-based medicine has been gaining interest from several researchers. Carvacrol and its isomeric compound, thymol, are plant-based extracts that possess several biological activities, such as antimalarial, anticancer, antifungal, and antibacterial. However, their efficacy is compromised by their poor bioavailability. Thus, medicinal scientists have explored the synthesis of hybrid compounds containing their pharmacophores to enhance their therapeutic efficacy and improve their bioavailability. Hence, this review is a comprehensive report on hybrid compounds containing carvacrol and its isomer, thymol, with potent anticancer and antibacterial agents reported between 2020 and 2024. Furthermore, their structural activity relationship (SAR) and recommended future strategies to further enhance their therapeutic effects will be discussed.
癌症在全球范围内被列为致命疾病，癌症病例和死亡人数的增加是由于获得有效治疗的机会有限。植物药的使用引起了许多研究人员的兴趣。香芹酚及其同系物百里酚是植物提取物，具有多种生物活性，如抗疟、抗癌、抗真菌和抗菌。然而，它们的生物利用度较差，限制了它们的疗效。因此，药用科学家探索了合成含有它们药效团的杂合化合物，以提高它们的治疗效果并改善它们的生物利用度。因此，这篇综述是对 2020 年至 2024 年期间报道的含有香芹酚及其同系物百里酚的具有潜在抗癌和抗菌作用的杂合化合物的全面报告。此外，还讨论了它们的构效关系（SAR）和建议的进一步提高治疗效果的未来策略。
