Department of Soil Sciences, University of Agronomic Sciences and Veterinary Medicine, 59 Mărăști Str., 011464 Bucharest, Romania.
Department of Inorganic and Organic Chemistry, Biochemistry and Catalysis, Faculty of Chemistry, University of Bucharest, 90-92 Panduri Str., S5, 050663 Bucharest, Romania.
Molecules. 2024 May 15;29(10):2321. doi: 10.3390/molecules29102321.
This review presents an overview of the biological applications of coordinative compounds based on unsaturated carboxylates accompanied by other ligands, usually N-based heterocyclic species. The interest in these compounds arises from the valuable antimicrobial and antitumor activities evidenced by some species, as well as from their ability to generate metal-containing polymers suitable for various medical purposes. Therefore, we describe the recently discovered aspects related to the synthesis, structure, and biological activity of a wide range of unsaturated carboxylate-containing species and metal ions, originating mostly from 3d series. The unsaturated carboxylates encountered in coordinative compounds are acrylate, methacrylate, fumarate, maleate, cinnamate, ferulate, coumarate, and itaconate. Regarding the properties of the investigated compounds, it is worth mentioning the good ability of some to inhibit the development of resistant strains or microbial biofilms on inert surfaces or, even more, exert antitumor activity against resistant cells. The ability of some species to intercalate into DNA strands as well as to scavenge ROS species is also addressed.
这篇综述介绍了基于不饱和羧酸盐和其他配体（通常为 N 杂环物种）的配位化合物在生物中的应用。这些化合物的研究兴趣源于一些物种具有有价值的抗菌和抗肿瘤活性，以及它们能够生成适合各种医疗用途的含金属聚合物的能力。因此，我们描述了与合成、结构和生物活性相关的广泛的不饱和羧酸盐含物种和金属离子的最新发现，这些物种主要来源于 3d 系列。配位化合物中遇到的不饱和羧酸盐有丙烯酸盐、甲基丙烯酸盐、富马酸盐、马来酸盐、肉桂酸盐、阿魏酸盐、香豆酸盐和衣康酸盐。关于所研究化合物的性质，值得一提的是，一些化合物具有很好的抑制惰性表面上抗性菌株或微生物生物膜发展的能力，甚至对抗性细胞具有抗肿瘤活性。一些物种能够嵌入 DNA 链以及清除 ROS 物种的能力也得到了研究。
