产后甲状腺炎和桥本甲状腺炎与HLA - DR4相关。
Post-partum thyroiditis and goitrous (Hashimoto's) thyroiditis are associated with HLA-DR4.
作者信息
Thompson C, Farid N R
出版信息
Immunol Lett. 1985;11(5-6):301-3. doi: 10.1016/0165-2478(85)90111-7.
PMID:3879239
Abstract
Using new panels of HLA-DR typing sera, we found an increase in the prevalence of HLA-DR4 in 21 patients with Hashimoto's thyroiditis (57%) and 32 patients with post-partum thyroiditis (53%) compared to controls (21%). Hashimoto's thyroiditis was previously found to be associated with HLA-DR5 and Dw5. We feel that the doubts raised by this study warrant the study of DR antigens in thyroid autoimmune disease using large panels of specific sera.
摘要
使用新的HLA - DR分型血清组，我们发现，与对照组（21%）相比，21例桥本甲状腺炎患者（57%）和32例产后甲状腺炎患者（53%）中HLA - DR4的患病率有所增加。此前发现桥本甲状腺炎与HLA - DR5和Dw5相关。我们认为，这项研究引发的疑问使得有必要使用大量特异性血清组来研究甲状腺自身免疫性疾病中的DR抗原。
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