Farid N R, Thompson C
Mol Biol Med. 1986 Feb;3(1):85-97.
We typed patient groups with type I diabetes (n = 78), Graves' disease (n = 81), goitrous autoimmune (n = 52), "silent" (n = 18) and postpartum thyroiditis (n = 15) for human leucocyte antigens (HLA) A, B, C, DR and DQ. The results were compared to those obtained from 256 healthy controls typed for HLA-A, -B, -C and 140 typed for -DR. All these 140 controls were genotyped. Previously described associations of DR3 (OR (odds ratio) = 2.68, p less than 0.005) and DR4 (OR = 3.26, p less than 0.0001) in type I diabetes is confirmed. In this series, however, HLA-DR3/DR4 heterozygotes were apparently at no greater risk for type I diabetes than DR3 or DR4 homozygotes. The relative risk conferred by DR3/DR4 heterozygotes (6.48) was less than that for DR3 homozygosity (2.8), suggesting a recessive major histocompatibility complex-related susceptibility to type I diabetes. Graves' disease was associated with DR3 (OR = 3.02, p less than 0.0005); the increased frequency of DR3 homozygotes in this series is consistent with recessive HLA-linked susceptibility to Graves' disease proposed on the basis of family data. Hashimoto's thyroiditis, on the other hand, was associated with HLA-DR4 (OR = 3.08, p less than 0.0001), the latter finding confirming our earlier report on 21 patients. The increase of HLA-DR4 in both post-partum and silent thyroiditis suggests that these conditions are immunogenetically related, and may well represent variants of chronic autoimmune thyroiditis.
我们对患有1型糖尿病（n = 78）、格雷夫斯病（n = 81）、甲状腺肿性自身免疫病（n = 52）、“寂静型”（n = 18）和产后甲状腺炎（n = 15）的患者群体进行了人类白细胞抗原（HLA）A、B、C、DR和DQ分型。将结果与256名进行了HLA - A、- B、- C分型的健康对照以及140名进行了 - DR分型的健康对照的结果进行比较。所有这140名对照都进行了基因分型。先前描述的1型糖尿病与DR3（优势比（OR）= 2.68，p小于0.005）和DR4（OR = 3.26，p小于0.0001）的关联得到了证实。然而，在这个系列中，HLA - DR3/DR4杂合子患1型糖尿病的风险显然并不比DR3或DR4纯合子更高。DR3/DR4杂合子赋予的相对风险（6.48）低于DR3纯合性的相对风险（2.8），这表明主要组织相容性复合体相关的1型糖尿病易感性是隐性的。格雷夫斯病与DR3相关（OR = 3.02，p小于0.0005）；在这个系列中DR3纯合子频率的增加与基于家族数据提出的格雷夫斯病隐性HLA连锁易感性一致。另一方面，桥本甲状腺炎与HLA - DR4相关（OR = 3.08，p小于0.0001），后一发现证实了我们先前对21名患者的报告。产后甲状腺炎和寂静型甲状腺炎中HLA - DR4的增加表明这些病症在免疫遗传学上相关，很可能代表慢性自身免疫性甲状腺炎的变体。
