氨苄西林与美西林或β-内酰胺酶抑制剂联合使用对氨苄西林耐药菌株的体外活性。
In-vitro activity of the combinations of ampicillin with mecillinam or with beta-lactamase inhibitors against strains resistant to ampicillin.
作者信息
Verbist L
出版信息
J Antimicrob Chemother. 1985 Dec;16(6):719-25. doi: 10.1093/jac/16.6.719.
The in-vitro activity of ampicillin, of mecillinam and of combinations of ampicillin with mecillinam, clavulanic acid or 6 beta-bromopenicillanic acid has been studied against 126 Enterobacteriaceae resistant to ampicillin. The combination of ampicillin with mecillinam showed synergy or addition in 60% of the combinations tested. Synergy was seen especially when the strains were resistant to mecillinam, indifference when they were susceptible to mecillinam. The combination of ampicillin with mecillinam was more active than the combination with clavulanic acid against Escherichia coli, Klebsiella and Enterobacter, but not against Proteus, Morganella and Providencia. The combination of ampicillin with clavulanic acid was more active than the combination with 6 beta-bromopenicillanic acid in E. coli, Klebsiella and Enterobacter strains.
研究了氨苄西林、美西林以及氨苄西林与美西林、克拉维酸或6-β-溴青霉烷酸组合对126株耐氨苄西林肠杆菌科细菌的体外活性。氨苄西林与美西林的组合在60%的测试组合中显示出协同或相加作用。尤其当菌株对美西林耐药时可见协同作用，当它们对美西林敏感时则为无差异作用。在针对大肠杆菌、克雷伯菌属和肠杆菌属时，氨苄西林与美西林的组合比与克拉维酸的组合更具活性，但对变形杆菌属、摩根菌属和普罗威登斯菌属则不然。在大肠杆菌、克雷伯菌属和肠杆菌属菌株中，氨苄西林与克拉维酸的组合比与6-β-溴青霉烷酸的组合更具活性。
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