Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 114202, Taiwan.
Division of Hematology/Oncology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 114202, Taiwan.
Medicina (Kaunas). 2024 Apr 25;60(5):706. doi: 10.3390/medicina60050706.
Ocular adnexa region (OAR) primary lymphomas are uncommon, accounting for 1-2% of non-Hodgkin lymphomas and 8% of extranodal lymphomas. Extranodal marginal zone lymphoma (EMZL) originates from several epithelial tissues, including the stomach, salivary gland, lung, small intestine, thyroid gland, and ocular adnexa region. Here, we report a 66-year-old female patient who was diagnosed with EMZL of OAR. In consideration of the possible side effect of radiotherapy, such as conjunctivitis, visual acuity impairment, and even retinal complications, she received six cycles of triweekly targeted chemotherapy with rituximab, cyclophosphamide, vincristine, and prednisone (R-CVP) without radiotherapy. Then, she remained in complete remission up to the present day.
眼附属器区域（OAR）原发性淋巴瘤并不常见，占非霍奇金淋巴瘤的 1-2%，占结外淋巴瘤的 8%。结外黏膜相关边缘区淋巴瘤（EMZL）来源于胃、唾液腺、肺、小肠、甲状腺和眼附属器等多种上皮组织。在此，我们报告了一例 66 岁女性患者，该患者被诊断为眼附属器 EMZL。由于考虑到放疗的可能副作用，如结膜炎、视力损害，甚至视网膜并发症，她接受了 6 个周期的每周 3 次利妥昔单抗、环磷酰胺、长春新碱和泼尼松（R-CVP）靶向化疗，而未接受放疗。此后，她一直处于完全缓解状态至今。
