围产期（先天性和新生儿期）肿瘤：110例报告

Perinatal (congenital and neonatal) neoplasms: a report of 110 cases.

作者信息

Isaacs H

出版信息

Pediatr Pathol. 1985;3(2-4):165-216. doi: 10.3109/15513818509078782.

Abstract

One hundred ten congenital and neonatal tumors encompassing a 25-year period are described and compared with similar published cases. Forty percent are classified as histologically malignant, and 65% of neonates with malignancies died. The types, frequency, and clinical features of neoplasms encountered in the perinatal period are markedly different from those observed in older children and adolescents. Their biological behavior and response to therapy are also dissimilar. Leukemia was responsible for the largest number of deaths followed by neuroblastoma and brain tumors.

摘要

本文描述了110例25年间的先天性和新生儿肿瘤，并与已发表的类似病例进行了比较。40%的肿瘤组织学上被归类为恶性，65%患有恶性肿瘤的新生儿死亡。围产期肿瘤的类型、发生率和临床特征与大龄儿童和青少年中观察到的明显不同。它们的生物学行为和对治疗的反应也不相同。白血病导致的死亡人数最多，其次是神经母细胞瘤和脑肿瘤。