Kleinknecht C, Levy M, Peix A, Broyer M, Courtecuisse V
J Pediatr. 1979 Dec;95(6):946-52. doi: 10.1016/s0022-3476(79)80281-4.
Of 33 children with membranous nephropathy screened for HBs Ag, 14 were found to be HBs Ag carriers, whereas HBs Ag was detected in 3 of 170 and 4 of 100 children with glomerular and nonglomerular kidney diseases, respectively. HBs Ag was often associated with acute hepatitis at onset (five patients) or with elevated transminases values. This high incidence and the prevalence of an unusual subtype (ayw2) suggest a relationship between HBs Ag and the glomerular lesions. Using immunofluorescence, however, HBs Ag could not be detected within the deposits, so that the nature of the relationship cannot be considered as established. The clinical outcome (50% remission), the plasma complement component disturbances, and findings by immunofluorescence did not differ from those observed in children with MGN without detectable HBs Ag.
在33名接受乙肝表面抗原（HBs Ag）筛查的膜性肾病患儿中，有14名被发现为HBs Ag携带者，而在170名肾小球肾病患儿和100名非肾小球肾病患儿中，分别有3名和4名检测到HBs Ag。HBs Ag在发病时常与急性肝炎（5例患者）或转氨酶值升高相关。这种高发病率以及一种不寻常亚型（ayw2）的流行提示HBs Ag与肾小球病变之间存在关联。然而，通过免疫荧光法，在沉积物中未检测到HBs Ag，因此这种关联的性质尚不能认定。临床结果（50%缓解）、血浆补体成分紊乱以及免疫荧光检查结果与未检测到HBs Ag的微小病变性肾小球肾炎患儿所观察到的情况并无差异。
