Takekoshi Y, Tanaka M, Shida N, Satake Y, Saheki Y, Matsumoto S
Lancet. 1978 Nov 18;2(8099):1065-8. doi: 10.1016/s0140-6736(78)91801-9.
Renal histology in 163 Japanese children, aged 3 to 15, with proteinuria and/or haematuria showed that 11 had membranous nephropathy (M.N) and the rest had various other renal diseases. Hepatitis-B-virus surface antigen (HBsAg) was identified, by a reversed passive haemagglutination method, in the serum of all the patients with M.N. but in only 4.6% of the patients with other renal diseases. 6 of the 11 mothers of the children with M.N. were positive for HBsAg, and 1 was positive for antibody to HBsAg (anti-HBs). These findings suggest that M.N. in Japanese children is mainly, if not exclusively, caused by hepatitis-B virus and that in most instances the virus is transmitted from mother to child.
对163名3至15岁有蛋白尿和/或血尿的日本儿童进行肾脏组织学检查发现，其中11人患有膜性肾病（M.N），其余患有各种其他肾脏疾病。通过反向被动血凝法在所有膜性肾病患者的血清中检测到乙肝病毒表面抗原（HBsAg），但在其他肾脏疾病患者中仅4.6%检测到。11名膜性肾病患儿的母亲中有6人HBsAg呈阳性，1人乙肝表面抗体（抗-HBs）呈阳性。这些发现表明，日本儿童的膜性肾病即使不是完全由乙肝病毒引起，也主要是由其引起，而且在大多数情况下，病毒是母婴传播的。
