Department of Neurology, Poznan University of Medical Sciences, 60-355 Poznan, Poland.
Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 9RX, UK.
Sensors (Basel). 2024 May 11;24(10):3045. doi: 10.3390/s24103045.
Early-morning off periods, causing early-morning akinesia, can lead to significant motor and nonmotor morbidity in levodopa-treated fluctuating Parkinson's disease (PD) cases. Despite validated bedside scales in clinical practice, such early-morning off periods may remain undetected unless specific wearable technologies, such as the Parkinson's KinetiGraph™ (PKG) watch, are used. We report five PD cases for whom the PKG detected early-morning off periods that were initially clinically undetected and as such, untreated. These five cases serve as exemplars of this clinical gap in care. Post-PKG assessment, clinicians were alerted and targeted therapies helped abolish the early-morning off periods.
清晨无活动期导致清晨运动不能，可导致左旋多巴治疗的帕金森病（PD）波动患者出现显著的运动和非运动并发症。尽管在临床实践中有经过验证的床边量表，但除非使用特定的可穿戴技术（如帕金森 KinetiGraph™（PKG）手表），否则可能会漏诊这些清晨无活动期。我们报告了五例 PD 病例，这些病例的 PKG 检测到了临床上最初未检测到的清晨无活动期，因此未得到治疗。这五个病例是这种护理临床空白的典型例子。在 PKG 评估后，临床医生得到了提醒，并采用靶向治疗来消除清晨无活动期。
