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用于脑组织检测的温度开关控制二次谐波模式传感器。

Temperature-Switch-Controlled Second Harmonic Mode Sensor for Brain-Tissue Detection.

作者信息

Li Xiang, Yang Cheng, Guo Chuming, Li Qijuan, Peng Chuan, Zhang Haifeng

机构信息

College of Electronic and Optical Engineering & College of Flexible Electronics (Future Technology), Nanjing University of Posts and Telecommunications, Nanjing 210023, China.

出版信息

Sensors (Basel). 2024 May 11;24(10):3065. doi: 10.3390/s24103065.

DOI:10.3390/s24103065
PMID:38793918
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11124983/
Abstract

Identifying brain-tissue types holds significant research value in the biomedical field of non-contact brain-tissue measurement applications. In this paper, a layered metastructure is proposed, and the second harmonic generation (SHG) in a multilayer metastructure is derived using the transfer matrix method. With the SHG conversion efficiency (CE) as the measurement signal, the refractive index ranges that can be distinguished are 1.231.31 refractive index unit (RIU) and 1.381.44 RIU, with sensitivities of 0.8597 RIU and 1.2967 RIU, respectively. It can distinguish various brain tissues, including gray matter, white matter, and low-grade glioma, achieving the function of a second harmonic mode sensor (SHMS). Furthermore, temperature has a significant impact on the SHG CE, which can be used to define the switch signal indicating whether the SHMS is functioning properly. When the temperature range is 291.4~307.9 Kelvin (K), the temperature switch is in the "open" state, and the optimal SHG CE is higher than 0.298%, indicating that the SHMS is in the working state. For other temperature ranges, the SHG CE will decrease significantly, indicating that the temperature switch is in the "off" state, and the SHMS is not working. By stimulating temperature and using the response of SHG CE, the temperature-switch function is achieved, providing a new approach for temperature-controlled second harmonic detection.

摘要

识别脑组织类型在非接触式脑组织测量应用的生物医学领域具有重要的研究价值。本文提出了一种分层亚结构，并使用转移矩阵法推导了多层亚结构中的二次谐波产生（SHG）。以SHG转换效率（CE）作为测量信号，可区分的折射率范围为1.231.31折射率单位（RIU）和1.381.44 RIU，灵敏度分别为0.8597 RIU和1.2967 RIU。它可以区分包括灰质、白质和低级别胶质瘤在内的各种脑组织，实现二次谐波模式传感器（SHMS）的功能。此外，温度对SHG CE有显著影响，可用于定义指示SHMS是否正常工作的开关信号。当温度范围为291.4~307.9开尔文（K）时，温度开关处于“开”状态，最佳SHG CE高于0.298%，表明SHMS处于工作状态。对于其他温度范围，SHG CE将显著下降，表明温度开关处于“关”状态，SHMS不工作。通过刺激温度并利用SHG CE的响应，实现了温度开关功能，为温控二次谐波检测提供了一种新方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6138/11124983/b62aad5021e3/sensors-24-03065-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6138/11124983/56d6b7d1f845/sensors-24-03065-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6138/11124983/61775d737a9d/sensors-24-03065-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6138/11124983/a9035c832a34/sensors-24-03065-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6138/11124983/3f0ebc23bbd8/sensors-24-03065-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6138/11124983/6da70a9a815e/sensors-24-03065-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6138/11124983/9b77b3b10211/sensors-24-03065-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6138/11124983/fe1da6b8cb28/sensors-24-03065-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6138/11124983/b3b83e398365/sensors-24-03065-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6138/11124983/b62aad5021e3/sensors-24-03065-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6138/11124983/56d6b7d1f845/sensors-24-03065-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6138/11124983/61775d737a9d/sensors-24-03065-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6138/11124983/a9035c832a34/sensors-24-03065-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6138/11124983/3f0ebc23bbd8/sensors-24-03065-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6138/11124983/6da70a9a815e/sensors-24-03065-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6138/11124983/9b77b3b10211/sensors-24-03065-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6138/11124983/fe1da6b8cb28/sensors-24-03065-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6138/11124983/b3b83e398365/sensors-24-03065-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6138/11124983/b62aad5021e3/sensors-24-03065-g009.jpg

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