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基于光子自旋霍尔效应的多层膜结构的高灵敏度雅努斯传感器及其在生物传感中的潜在应用。

High-Sensitivity Janus Sensor Enabled by Multilayered Metastructure Based on the Photonic Spin Hall Effect and Its Potential Applications in Bio-Sensing.

机构信息

College of Electronic and Optical Engineering & College of Flexible Electronics (Future Technology), Nanjing University of Posts and Telecommunications, Nanjing 210023, China.

出版信息

Sensors (Basel). 2024 Sep 6;24(17):5796. doi: 10.3390/s24175796.

Abstract

The refractive index (RI) of biological tissues is a fundamental material parameter that characterizes how light interacts with tissues, making accurate measurement of RI crucial for biomedical diagnostics and environmental monitoring. A Janus sensor (JBS) is designed in this paper, and the photonic spin Hall effect (PSHE) is used to detect subtle changes in RI in biological tissues. The asymmetric arrangement of the dielectric layers breaks spatial parity symmetry, resulting in significantly different PSHE displacements during the forward and backward propagation of electromagnetic waves, thereby realizing the Janus effect. The designed JBS can detect the RI range of 1.3~1.55 RIU when electromagnetic waves are incident along the +-axis, with a sensitivity of 96.29°/refractive index unit (RIU). In the reverse direction, blood glucose concentrations are identified by the JBS, achieving a sensitivity of 18.30°/RIU. Detecting different RI range from forward and backward scales not only overcomes the limitation that single-scale sensors can only detect a single RI range, but also provides new insights and applications for optical biological detection through high-sensitivity, label-free and non-contact detection.

摘要

生物组织的折射率(RI)是一个基本的材料参数,它描述了光与组织的相互作用方式,因此准确测量 RI 对于生物医学诊断和环境监测至关重要。本文设计了一种 Janus 传感器(JBS),并利用光子自旋霍尔效应(PSHE)来检测生物组织中 RI 的细微变化。介电层的非对称排列打破了空间奇偶对称,导致电磁波正向和反向传播时 PSHE 位移有显著差异,从而实现了 Janus 效应。当电磁波沿 +- 轴入射时,设计的 JBS 可以检测到 1.3~1.55 RIU 的 RI 范围,灵敏度为 96.29°/折射率单位(RIU)。在相反方向上,JBS 可以通过检测血糖浓度来实现,灵敏度为 18.30°/RIU。通过前后尺度检测不同的 RI 范围不仅克服了单尺度传感器只能检测单一 RI 范围的局限性,还通过高灵敏度、无标记和非接触检测为光学生物检测提供了新的见解和应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fb2/11397867/b9c724abf770/sensors-24-05796-g001.jpg

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