Department of Molecular and Cellular Biology, Scripps Research, 10550 North Torrey Pines Road, MBB-102, La Jolla, CA 92037, United States.
Department of Systems Biomedicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-Ku, Tokyo 113-8510, Japan.
J Bone Miner Res. 2024 Aug 5;39(7):814-820. doi: 10.1093/jbmr/zjae074.
Tendons play an important role in the maintenance of motor function by connecting muscles and bones and transmitting forces. Particularly, the role of mechanical stress has primarily focused on the key mechanism of tendon homeostasis, with much research on this topic. With the recent development of molecular biological techniques, the mechanisms of mechanical stress sensing and signal transduction have been gradually elucidated with the identification of mechanosensor in tendon cells and the master regulator in tendon development. This review provides a comprehensive overview of the structure and function of tendon tissue, including the role for physical performance and the detailed mechanism of mechanotransduction in its regulation. An important lesson is that the role of mechanotransduction in tendon tissue is only partially clarified, indicating the complexity of the mechanisms of motor function and fueling increasing interest in uncovering these mechanisms.
肌腱通过连接肌肉和骨骼并传递力量，在维持运动功能方面发挥着重要作用。特别是，机械应力的作用主要集中在肌腱稳态的关键机制上，对此已有大量研究。随着分子生物学技术的发展，肌腱细胞中机械感受器的鉴定和肌腱发育中的主调控因子的发现，机械应力感应和信号转导的机制逐渐得到阐明。本文综述了肌腱组织的结构和功能，包括其在运动功能中的作用以及机械转导在其调节中的详细机制。一个重要的教训是，机械转导在肌腱组织中的作用仅部分阐明，这表明运动功能的机制非常复杂，这也激发了人们对揭示这些机制的浓厚兴趣。
