Department of Medical Physics, School of Medicine, Iran University of Medical Sciences, Junction of Shahid Hemmat and Chamran Expressway, Tehran, Iran.
Department of Medical Physics and Radiation Biology Research Center, Iran University of Medical Sciences, Junction of Shahid Hemmat and Chamran Expressway, Tehran, Iran.
Clin Transl Oncol. 2018 Dec;20(12):1502-1521. doi: 10.1007/s12094-018-1896-2. Epub 2018 Jun 4.
Cancer stem cells (CSCs) have been identified as the main center of tumor therapeutic resistance. They are highly resistant against current cancer therapy approaches particularly radiation therapy (RT). Recently, a wide spectrum of physical methods has been proposed to treat CSCs, including high energetic particles, hyperthermia (HT), nanoparticles (NPs) and combination of these approaches. In this review article, the importance and benefits of the physical CSCs therapy methods such as nanomaterial-based heat treatments and particle therapy will be highlighted.
癌症干细胞 (CSCs) 已被确定为肿瘤治疗耐药的主要中心。它们对当前的癌症治疗方法，特别是放射治疗 (RT)，具有高度的耐药性。最近，已经提出了广泛的物理方法来治疗 CSCs，包括高能粒子、高热疗 (HT)、纳米颗粒 (NPs) 以及这些方法的组合。在这篇综述文章中，将重点强调基于纳米材料的热疗和粒子疗法等物理 CSCs 治疗方法的重要性和益处。
