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在行为/清醒猴子的外苍白球中进行细胞外记录的方案。

Protocol for extracellular recordings in the external globus pallidus of the behaving/awake monkey.

机构信息

Department of Medical Neuroscience, Institute of Medical Research Israel-Canada (IMRIC), The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel.

Department of Neurosurgery, Hadassah Medical Center, Jerusalem 91120, Israel.

出版信息

STAR Protoc. 2024 Jun 21;5(2):103081. doi: 10.1016/j.xpro.2024.103081. Epub 2024 May 24.

DOI:10.1016/j.xpro.2024.103081
PMID:38795352
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11144808/
Abstract

Extracellular recordings in behaving animals are useful for establishing associations between neuronal activity and behavior. Here, we describe how to record in the external globus pallidus (GPe) of monkeys engaged in a behavioral task. We detail the stereotaxic surgery for chamber and head-holder implantation, the post-operative MRI scan to ascertain the GPe coordinates and validate the position of the chamber, and the data collection. This protocol makes it possible to examine the electrophysiological features of GPe neurons in behaving monkeys. For complete details on the use and execution of this protocol, please refer to Katabi et al..

摘要

在行为动物中进行细胞外记录对于建立神经元活动与行为之间的关联非常有用。在这里，我们描述了如何在进行行为任务的猴子的外苍白球（GPe）中进行记录。我们详细介绍了室和头架植入的立体定向手术、术后 MRI 扫描以确定 GPe 坐标和验证室的位置以及数据采集。该方案使我们能够检查行为猴子中 GPe 神经元的电生理特征。有关此方案的使用和执行的完整详细信息，请参阅 Katabi 等人的研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9712/11144808/11104d96e6fa/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9712/11144808/e1a65fb740f0/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9712/11144808/201b4b59ef9b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9712/11144808/732cdf9893ee/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9712/11144808/a47659f640a6/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9712/11144808/92669c715d28/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9712/11144808/11104d96e6fa/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9712/11144808/e1a65fb740f0/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9712/11144808/201b4b59ef9b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9712/11144808/732cdf9893ee/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9712/11144808/a47659f640a6/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9712/11144808/92669c715d28/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9712/11144808/11104d96e6fa/gr5.jpg

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