The Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA.
The Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA.
Curr Opin Immunol. 2024 Apr;87:102426. doi: 10.1016/j.coi.2024.102426. Epub 2024 May 24.
In this review, we provide an overview of the intricate host-virus interactions that have emerged from the study of SARS-CoV-2 infection. We focus on the antiviral mechanisms of interferon-stimulated genes (ISGs) and their modulation of viral entry, replication, and release. We explore the role of a selection ISGs, including BST2, CD74, CH25H, DAXX, IFI6, IFITM1-3, LY6E, NCOA7, PLSCR1, OAS1, RTP4, and ZC3HAV1/ZAP, in restricting SARS-CoV-2 infection and discuss the virus's countermeasures. By synthesizing the latest research on SARS-CoV-2 and host antiviral responses, this review aims to provide a deeper understanding of the antiviral state of the cell under SARS-CoV-2 and other viral infections, offering insights for the development of novel antiviral strategies and therapeutics.
在这篇综述中，我们概述了从 SARS-CoV-2 感染研究中出现的复杂的宿主-病毒相互作用。我们专注于干扰素刺激基因 (ISGs) 的抗病毒机制及其对病毒进入、复制和释放的调节。我们探讨了一系列 ISGs 的作用，包括 BST2、CD74、CH25H、DAXX、IFI6、IFITM1-3、LY6E、NCOA7、PLSCR1、OAS1、RTP4 和 ZC3HAV1/ZAP，它们在限制 SARS-CoV-2 感染中的作用，并讨论了病毒的对策。通过综合 SARS-CoV-2 和宿主抗病毒反应的最新研究，本综述旨在更深入地了解 SARS-CoV-2 和其他病毒感染下细胞的抗病毒状态，为开发新型抗病毒策略和疗法提供思路。
