抗生素对免疫系统的影响。III. 鸡白细胞体外细胞功能的研究。

The influence of antibiotics on the immune system. III. Investigations on the cellular functions of chicken leukocytes in vitro.

作者信息

Grondel J L, Angenent G C, Egberts E

出版信息

Vet Immunol Immunopathol. 1985 Dec;10(4):307-16. doi: 10.1016/0165-2427(85)90020-0.

Abstract

Tetracyclines are bacteriostatic antibiotics widely used in veterinary medicine. It is reported here that the tetracycline analogue oxytetracycline (OxyTC) interferes with the mitogenic response of chicken leukocytes. A dose-dependent suppression of lectin stimulation of peripheral blood and spleen leukocytes was observed. The kinetics of the DNA-synthetic activity were seriously affected. The antimicrobial agent does not seem to have any effect on interleukin 2 (IL-2) production, whereas the uptake of 3H-thymidine by IL-2-dependent T cell blasts was severely reduced. It is concluded that the T cell blast is the target for OxyTC.

摘要

四环素是广泛应用于兽医学的抑菌性抗生素。本文报道四环素类似物土霉素（OxyTC）会干扰鸡白细胞的促有丝分裂反应。观察到外周血和脾脏白细胞的凝集素刺激呈剂量依赖性抑制。DNA合成活性的动力学受到严重影响。这种抗菌剂似乎对白细胞介素2（IL-2）的产生没有任何影响，而IL-2依赖性T细胞母细胞对3H-胸腺嘧啶核苷的摄取则严重减少。得出的结论是，T细胞母细胞是土霉素的作用靶点。