心血管临床试验基地的地理位置接近度：美国的全国性分析。

Geographic proximity to cardiovascular clinical trial sites: A National analysis in the United States.

机构信息

Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, United States.

Surgical Services, Louis Stokes VA Medical Center, Cleveland, OH, United States; Case Western Reserve University School of Medicine, Cleveland, OH, United States.

出版信息

Curr Probl Cardiol. 2024 Aug;49(8):102683. doi: 10.1016/j.cpcardiol.2024.102683. Epub 2024 May 23.

DOI:10.1016/j.cpcardiol.2024.102683

PMID:38795807

Abstract

INTRODUCTION

Suboptimal geographical access to cardiovascular clinical trial sites (CV-CTS) may be a cause of inadequate demographic representation in contemporary trials. Thus, we investigate access to CV-CTS in the US.

METHODS

We obtained the location of CV-CTS from Clinicaltrials.gov. We calculated the distance in kilometers from each ZIP code to the nearest CV-CTS, stratifying our results based on urban/rural setting, sex and race.

RESULTS

We identified a total of 10,506 studies in 4,630 US ZIP codes (10.5 %), of those only 237 (5 %) were rural. The overall median CV-CTS distance was 5.8 km (IQR: 2.7, 15.8). For urban residents, this distance was 4.5 km (IQR: 2.3, 9.2), while for rural residents, it was 24.2 km (IQR: 13.8, 42.2).

RESULTS

We revealed important disparities involving geographical proximity to cardiovascular clinical trial sites. Increasing the representation of these populations in clinical trials is paramount to improving the applicability of their findings to real-world settings.

摘要

简介

心血管临床试验地点（CV-CTS）地理位置不理想可能是当代试验中代表性不足的一个原因。因此，我们调查了美国 CV-CTS 的可及性。

方法

我们从 Clinicaltrials.gov 获得了 CV-CTS 的位置。我们计算了每个邮政编码到最近的 CV-CTS 的距离，根据城市/农村环境、性别和种族对结果进行分层。

结果

我们在 4630 个美国邮政编码中总共确定了 10506 项研究（占 10.5%），其中只有 237 项（占 5%）是农村的。总体 CV-CTS 距离中位数为 5.8 公里（IQR：2.7，15.8）。对于城市居民，这个距离是 4.5 公里（IQR：2.3，9.2），而对于农村居民，这个距离是 24.2 公里（IQR：13.8，42.2）。