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Antibody-drug conjugates are active in patients with HER2-positive breast cancer brain metastases: where do we go from here?

作者信息

Sammons S, Lin N U

机构信息

Medical Oncology, Dana-Farber Cancer Institute, Boston; Breast Oncology Program, Dana-Farber Brigham Cancer Center, Boston; Harvard Medical School, Boston, USA.

Medical Oncology, Dana-Farber Cancer Institute, Boston; Breast Oncology Program, Dana-Farber Brigham Cancer Center, Boston; Harvard Medical School, Boston, USA.

出版信息

ESMO Open. 2024 May;9(5):102990. doi: 10.1016/j.esmoop.2024.102990. Epub 2024 Apr 24.

DOI:10.1016/j.esmoop.2024.102990
PMID:38796286
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11145748/
Abstract
摘要

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本文引用的文献

1
Trastuzumab deruxtecan versus trastuzumab emtansine in HER2-positive metastatic breast cancer patients with brain metastases from the randomized DESTINY-Breast03 trial.曲妥珠单抗-德鲁替康与曲妥珠单抗-美坦新在随机 DESTINY-Breast03 试验中用于 HER2 阳性转移性乳腺癌伴脑转移患者的比较。
ESMO Open. 2024 May;9(5):102924. doi: 10.1016/j.esmoop.2024.102924. Epub 2024 Apr 24.
2
Rise of Antibody-Drug Conjugates: The Present and Future.抗体药物偶联物的兴起：现状与未来。
Am Soc Clin Oncol Educ Book. 2023 May;43:e390094. doi: 10.1200/EDBK_390094.
3
Trastuzumab deruxtecan versus trastuzumab emtansine in patients with HER2-positive metastatic breast cancer: updated results from DESTINY-Breast03, a randomised, open-label, phase 3 trial.曲妥珠单抗-德鲁替康对比曲妥珠单抗-美坦新用于治疗 HER2 阳性转移性乳腺癌患者：来自随机、开放标签、III 期 DESTINY-Breast03 研究的更新结果。
Lancet. 2023 Jan 14;401(10371):105-117. doi: 10.1016/S0140-6736(22)02420-5. Epub 2022 Dec 7.
4
Tucatinib vs Placebo, Both in Combination With Trastuzumab and Capecitabine, for Previously Treated ERBB2 (HER2)-Positive Metastatic Breast Cancer in Patients With Brain Metastases: Updated Exploratory Analysis of the HER2CLIMB Randomized Clinical Trial.图卡替尼对比安慰剂，均联合曲妥珠单抗和卡培他滨，用于治疗先前接受过治疗的 ERBB2（HER2）阳性转移性乳腺癌且伴有脑转移的患者：HER2CLIMB 随机临床试验的更新探索性分析。
JAMA Oncol. 2023 Feb 1;9(2):197-205. doi: 10.1001/jamaoncol.2022.5610.
5
Trastuzumab deruxtecan in HER2-positive breast cancer with brain metastases: a single-arm, phase 2 trial.曲妥珠单抗-德鲁替康治疗 HER2 阳性乳腺癌伴脑转移：一项单臂、2 期临床试验。
Nat Med. 2022 Sep;28(9):1840-1847. doi: 10.1038/s41591-022-01935-8. Epub 2022 Aug 8.
6
Trastuzumab deruxtecan in patients with central nervous system involvement from HER2-positive breast cancer: The DEBBRAH trial.曲妥珠单抗 deruxtecan 治疗人表皮生长因子受体 2 阳性乳腺癌伴中枢神经系统转移患者：DEBBRAH 试验。
Neuro Oncol. 2023 Jan 5;25(1):157-166. doi: 10.1093/neuonc/noac144.
7
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Cell Rep. 2022 May 24;39(8):110839. doi: 10.1016/j.celrep.2022.110839.
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Efficacy of Neratinib Plus Capecitabine in the Subgroup of Patients with Central Nervous System Involvement from the NALA Trial.NALA 试验中中枢神经系统转移亚组患者接受奈拉替尼联合卡培他滨的疗效。
Oncologist. 2021 Aug;26(8):e1327-e1338. doi: 10.1002/onco.13830. Epub 2021 Jun 7.
9
Intracranial Efficacy and Survival With Tucatinib Plus Trastuzumab and Capecitabine for Previously Treated HER2-Positive Breast Cancer With Brain Metastases in the HER2CLIMB Trial.在 HER2CLIMB 试验中，曲妥珠单抗联合卡培他滨治疗既往治疗的 HER2 阳性乳腺癌伴脑转移的颅内疗效和生存。
J Clin Oncol. 2020 Aug 10;38(23):2610-2619. doi: 10.1200/JCO.20.00775. Epub 2020 May 29.
10
TBCRC 022: A Phase II Trial of Neratinib and Capecitabine for Patients With Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer and Brain Metastases.TBCRC 022：曲妥珠单抗联合卡培他滨治疗人表皮生长因子受体 2 阳性乳腺癌伴脑转移的 II 期临床试验。
J Clin Oncol. 2019 May 1;37(13):1081-1089. doi: 10.1200/JCO.18.01511. Epub 2019 Mar 12.