Key Laboratory of Analytical Science and Technology of Hebei Province, College of Chemistry and Materials Science, Hebei University, Baoding 071002, PR China; Analysis and Testing Center, Inner Mongolia University of Science and Technology, Baotou 014010, PR China.
Key Laboratory of Analytical Science and Technology of Hebei Province, College of Chemistry and Materials Science, Hebei University, Baoding 071002, PR China; State Key Laboratory of New Pharmaceutical Preparations and Excipients, Baoding 071002, PR China.
Food Chem. 2024 Oct 1;454:139796. doi: 10.1016/j.foodchem.2024.139796. Epub 2024 May 22.
This study aimed to present a selective and effective method for analyzing quinolones (QNs) in food matrix. Herein, a NiFeO-based magnetic sodium disulfonate covalent organic framework (NiFeO/COF) was prepared using a simple solvent-free grinding method, and was adopted as a selective adsorbent for magnetic solid phase extraction of QNs. Coupled with UHPLC-Q-Orbitrap HRMS, an efficient method for simultaneous detection of 18 kinds of QNs was established. The method exhibited good linearity (0.01-100 ng g), high sensitivity (LODs ranging from 0.0011 to 0.0652 ng g) and precision (RSDs below 9.5%). Successful extraction of QNs from liver and kidney samples was achieved with satisfactory recoveries ranging from 82.2% to 108.4%. The abundant sulfonate functional groups on NiFeO/COF facilitated strong affinity to QNs through electrostatic and hydrogen bonding interactions. The proposed method provides a new idea for the extraction of contaminants with target selectivity.
本研究旨在提供一种用于分析食品基质中喹诺酮类药物（QNs）的选择性和有效方法。在此，采用简单的无溶剂研磨法制备了基于 NiFeO 的磁性磺酸钠共价有机骨架（NiFeO/COF），并将其用作 QNs 的磁性固相萃取的选择性吸附剂。结合 UHPLC-Q-Orbitrap HRMS，建立了同时检测 18 种 QNs 的有效方法。该方法表现出良好的线性（0.01-100ng g）、高灵敏度（LOD 范围为 0.0011-0.0652ng g）和精密度（RSD 低于 9.5%）。成功地从肝和肾样品中提取了 QNs，回收率在 82.2%至 108.4%之间。NiFeO/COF 上丰富的磺酸盐官能团通过静电和氢键相互作用对 QNs 具有很强的亲和力。该方法为具有目标选择性的污染物提取提供了新的思路。
