Poliquin J, Ryan A, Bone R, Catanzaro A
J Otolaryngol. 1979 Oct;8(5):385-9.
Immunocompetence of the middle ear was studied in guinea pigs in two series of experiments. The first, afferent phase, consisted of grafting iso and allografts in the guinea pig's middle ear to sensitize the animals which were later to receive a skin graft on the back. The second, efferent phase, first sensitized the animals with a skin graft on their back and later in the middle ear. The results show a rather low capacity of the middle ear to elicit a second-set rejection of the skin grafts. This lack of sensitization is explained by the authors by the concept of tolerance.
在两个系列的实验中，对豚鼠中耳的免疫能力进行了研究。第一个系列，即传入阶段，包括在豚鼠中耳移植同基因和异基因移植物，以使动物致敏，这些动物随后将接受背部皮肤移植。第二个系列，即传出阶段，首先通过在动物背部进行皮肤移植使其致敏，随后在中耳进行移植。结果表明，中耳引发皮肤移植二次排斥反应的能力相当低。作者用耐受性概念解释了这种缺乏致敏的现象。
