奥尼永永热：一种被忽视的蚊媒病毒病。
O'nyong-nyong fever: a neglected mosquito-borne viral disease.
机构信息
a Department of Infectious Diseases , Istituto Superiore di Sanità , Roma , Italy.
b Department of Microbiology and Immunology and Institute for Human Infections and Immunity , University of Texas Medical Branch , Galveston , TX , USA.
出版信息
Pathog Glob Health. 2017 Sep;111(6):271-275. doi: 10.1080/20477724.2017.1355431. Epub 2017 Aug 22.
Abstract
O'nyong nyong virus (ONNV), a mosquito-borne Alphavirus, is primarily transmitted through the bite of Anopheles funestus and Anopheles gambiae mosquitoes, which are also malaria parasite vectors in Africa. The virus, first isolated in Uganda in 1959, is endemic in sub-Saharan Africa and has caused several major outbreaks both in West and East Africa. ONNV fever, characterized by severe arthralgia, is similar to chikungunya fever, with the exception of cervical lymphadenitis, which is peculiar to the former. Prevention measures do not differ from those adopted against malaria parasite transmission. Effective vaccines and drugs are not available, but animal models suggest that vaccine candidates against CHIKV may also confer protection against ONNV.
摘要
奥尼永永病毒（ONNV）是一种由蚊子传播的阿尔法病毒，主要通过携带疟原虫的恶性疟原虫和冈比亚按蚊传播。该病毒于 1959 年首次在乌干达分离得到，在撒哈拉以南非洲流行，并在西非和东非多次引发大规模疫情。ONNV 热的特征是严重的关节痛，类似于基孔肯雅热，但前者有独特的颈淋巴结炎。预防措施与预防疟原虫传播的措施相同。目前尚无有效的疫苗和药物，但动物模型表明，针对 CHIKV 的疫苗候选物也可能对 ONNV 提供保护。
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