LINC 复合物之外的生命活动——SUN 蛋白是否具有与 LINC 无关的功能？
Life outside the LINC complex - Do SUN proteins have LINC-independent functions?
机构信息
Altos Labs, Cambridge Institute of Science, Cambridge, UK.
Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh, North Carolina, USA.
出版信息
Bioessays. 2024 Aug;46(8):e2400034. doi: 10.1002/bies.202400034. Epub 2024 May 27.
Sad1 and UNC84 (SUN) and Klarsicht, ANC-1, and Syne homology (KASH) proteins interact at the nuclear periphery to form the linker of nucleoskeleton and cytoskeleton (LINC) complex, spanning the nuclear envelope (NE) and connecting the cytoskeleton with the nuclear interior. It is now well-documented that several cellular functions depend on LINC complex formation, including cell differentiation and migration. Intriguingly, recent studies suggest that SUN proteins participate in cellular processes where their association with KASH proteins may not be required. Building on this recent research, we elaborate on the hypothesis that SUN proteins may perform LINC-independent functions and discuss the modalities that may allow SUN proteins to function at the INM when they are not forming LINC complex.
Sad1 和 UNC84（SUN）以及 Klarsicht、ANC-1 和 Syne 同源（KASH）蛋白在核周相互作用形成核骨架和细胞骨架（LINC）连接复合物，跨越核膜（NE）并将细胞骨架与核内部连接起来。现在已经有充分的文献证明，几个细胞功能依赖于 LINC 复合物的形成，包括细胞分化和迁移。有趣的是，最近的研究表明，SUN 蛋白参与了一些细胞过程，它们与 KASH 蛋白的结合可能不是必需的。基于这一最新研究，我们详细阐述了 SUN 蛋白可能发挥不依赖于 LINC 的功能的假设，并讨论了可能允许 SUN 蛋白在不形成 LINC 复合物时在 INM 中发挥功能的方式。
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