老年人虚弱与抑郁症风险增加相关：一项系统评价和荟萃分析
Frailty in the Elderly is Associated with an Increased Risk of Depression: A Systematic Review and Meta-Analysis.
作者信息
Zhou Jianguo, Chen Honghui, Lin Cong
机构信息
Department of EICU, Wenzhou Central Hospital/The Dingli Clinical College of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Department of General Medical Practice, Wenzhou Central Hospital, Wenzhou, Zhejiang, China.
出版信息
Alpha Psychiatry. 2024 Mar 1;25(2):175-182. doi: 10.5152/alphapsychiatry.2024.231362. eCollection 2024 Mar.
OBJECTIVE
The aim was to systematically review the association between depression and frailty in the elderly.
METHODS
Databases such as PubMed, Web of Science, Embase, and Scopus were searched for articles on the link between the risk of depression and frailty since the creation of the databases to September 1, 2023. A pair of investigators collaboratively conducted the screening, collected data, and evaluated the potential for bias in the included studies. R software was utilized for meta-synthesis.
RESULTS
Eight cohort studies comprising 13 043 participants and 14 854 senior individuals with depression were included. The meta-analysis showed that there was a significant connection regarding frailty and the incidence of depression among the elderly (Risk Ratio [RR] = 3.26, 95% Confidence Interval [CI]: 1.68-6.32). Subgroup evaluations showed that there was no association between frailty and depression in the community-dwelling elderly (RR = 2.28, 95% CI: 0.644-8.102) and in the elderly patients with depression assessed by Center for Epidemiological Studies Depression Scale (CES-D) (RR = 5.82, 95% CI: 0.481-70.526).
CONCLUSION
Frailty is correlated with the risk of depression in the elderly. Frailty is a contributing factor to depression in the elderly.
目的
旨在系统评价老年人抑郁与衰弱之间的关联。
方法
检索了PubMed、Web of Science、Embase和Scopus等数据库，查找自数据库创建至2023年9月1日有关抑郁风险与衰弱之间联系的文章。由两名研究人员共同进行筛选、收集数据并评估纳入研究中的偏倚可能性。使用R软件进行荟萃综合分析。
结果
纳入了八项队列研究，共13043名参与者和14854名患有抑郁症的老年人。荟萃分析表明，老年人中衰弱与抑郁症发病率之间存在显著关联（风险比[RR]=3.26，95%置信区间[CI]：1.68 - 6.32）。亚组评估显示，社区居住老年人中衰弱与抑郁之间无关联（RR = 2.28，95% CI：0.644 - 8.102），以及在通过流行病学研究中心抑郁量表（CES - D）评估的老年抑郁症患者中也无关联（RR = 5.82，95% CI：0.481 - 70.526）。
结论
衰弱与老年人患抑郁症的风险相关。衰弱是老年人患抑郁症的一个促成因素。
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