Faculty of Medicine, University of Brasilia, Brasilia, Federal District, Brazil.
Faculty of Gama, University of Brasilia, Brasilia, Federal District, Brazil.
PLoS One. 2021 Mar 4;16(3):e0247766. doi: 10.1371/journal.pone.0247766. eCollection 2021.
Studies have shown an association between depression and frailty, even though the literature has not reached a consensus regarding how these syndromes interact. Although prospective cohort studies on this topic are still scarce, they could contribute to understanding this relationship. We aimed to observe whether depressive symptoms are risk factors for the onset of frailty among older adults living in São Paulo, Brazil.
Prospective cohort study using the "Health, Well-being and Aging" (SABE) Study databases of 2006 and 2010. The sample was representative of the community-dwelling older adults living in São Paulo, and it is composed of non-frail men and women aged 60 years and older without cognitive decline. We calculated the frailty incidence rate between older adults with and without depressive symptoms and calculated the incidence rate ratio. Multiple analysis was carried out through Poisson regression with robust variance estimation.
The initial sample (n = 1,109) presented a mean age of 72 years (from 60 to 96) and 61.1% were women. The final sample was composed of 830 individuals, and the mean follow-up time in the study was 3.8 years. After adjusting the model, depressive symptoms did not predict the onset of frailty at follow-up.
Depressive symptoms were not shown to be a risk factor for frailty among older adults living in São Paulo in this study.
研究表明抑郁与虚弱之间存在关联，尽管文献尚未就这两种综合征如何相互作用达成共识。尽管关于这个主题的前瞻性队列研究仍然很少，但它们可能有助于理解这种关系。我们旨在观察抑郁症状是否是巴西圣保罗地区老年人群发生虚弱的危险因素。
这是一项使用 2006 年和 2010 年“健康、福利和老龄化”（SABE）研究数据库的前瞻性队列研究。该样本代表了居住在圣保罗的社区老年人，由无认知能力下降的 60 岁及以上非虚弱男性和女性组成。我们计算了有和无抑郁症状的老年人之间的虚弱发生率，并计算了发病率比。通过具有稳健方差估计的泊松回归进行多因素分析。
初始样本（n=1109）的平均年龄为 72 岁（60-96 岁），其中 61.1%为女性。最终样本由 830 人组成，研究中的平均随访时间为 3.8 年。调整模型后，抑郁症状不能预测随访时虚弱的发生。
在这项研究中，抑郁症状并未被证明是导致巴西圣保罗地区老年人虚弱的危险因素。
