Godbole Amruta M, Chen Aimin, Vuong Ann M
Department of Epidemiology and Biostatistics, University of Nevada Las Vegas, School of Public Health, Las Vegas, Nevada.
Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Environ Epidemiol. 2024 May 6;8(3):e310. doi: 10.1097/EE9.0000000000000310. eCollection 2024 Jun.
Toxicological studies indicate that neonicotinoids may be associated with disruptions in liver function due to an increase in oxidative stress. There are scant epidemiological studies investigating the chronic hepatotoxic effects of neonicotinoids.
To examine the association between detectable concentrations of parent neonicotinoids and neonicotinoid metabolites with liver function markers among US adults, and whether sex modifies this association.
National Health and Nutrition Examination Survey 2015-2016 data were used to estimate associations between detectable neonicotinoids and serum alkaline phosphatase (ALP), alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transaminase (GGT), albumin, total bilirubin, total protein, and Hepatic Steatosis Index (HSI) using multiple linear regression.
Detectable levels of -desmethyl-acetamiprid were associated with a decrease in GGT (β = -3.54 unit/l; 95% confidence interval [CI] = -6.48, -0.61) and detectable levels of 5-hydroxy-imidacloprid were associated with a decrease in HSI (β = -1.11; 95% CI = -2.14, -0.07). Sex modified the association between any parent neonicotinoid and ALP ( = 0.064) and the association between clothianidin and ALP ( = 0.019), with a pattern of positive associations in males and inverse associations in females, though stratified associations did not reach statistical significance. Sex also modified the association between 5-hydroxy-imidacloprid and total protein ( = 0.062), with a significant positive association in females (β = 0.14 g/dl; 95% CI = 0.03, 0.25) and a null association in males.
Detectable concentrations of neonicotinoid metabolites were inversely associated with GGT and HSI in US adults. Evidence suggests neonicotinoids may influence liver function differently depending on sex. Future research is recommended to replicate the findings as the study was limited in its cross-sectional nature and inability to examine continuous neonicotinoid concentrations with liver function.
毒理学研究表明，由于氧化应激增加，新烟碱类可能与肝功能紊乱有关。调查新烟碱类慢性肝毒性作用的流行病学研究很少。
研究美国成年人中可检测到的母体新烟碱类及其代谢物浓度与肝功能标志物之间的关联，以及性别是否会改变这种关联。
使用2015 - 2016年国家健康与营养检查调查数据，通过多元线性回归估计可检测到的新烟碱类与血清碱性磷酸酶（ALP）、丙氨酸氨基转移酶、天冬氨酸氨基转移酶、γ-谷氨酰转移酶（GGT）、白蛋白、总胆红素、总蛋白和肝脂肪变性指数（HSI）之间的关联。
可检测到的去甲基啶虫脒水平与GGT降低有关（β = -3.54单位/升；95%置信区间[CI] = -6.48，-0.61），可检测到的5-羟基吡虫啉水平与HSI降低有关（β = -1.11；95% CI = -2.14，-0.07）。性别改变了任何母体新烟碱类与ALP之间的关联（P = 0.064）以及噻虫胺与ALP之间的关联（P = 0.019），男性呈现正相关，女性呈现负相关，尽管分层关联未达到统计学显著性。性别还改变了5-羟基吡虫啉与总蛋白之间的关联（P = 0.062），女性有显著正相关（β = 0.14克/分升；95% CI = 0.03，0.25），男性无关联。
在美国成年人中，可检测到的新烟碱类代谢物浓度与GGT和HSI呈负相关。有证据表明，新烟碱类对肝功能的影响可能因性别而异。由于本研究具有横断面性质且无法检查新烟碱类浓度与肝功能的连续关系，建议未来研究重复这些发现。
