Reza-Zaldívar Edwin E, Jacobo-Velázquez Daniel A
Tecnologico de Monterrey, Institute for Obesity Research, Ave. General Ramon Corona 2514, Zapopan 45201, Jalisco, Mexico.
Tecnologico de Monterrey, Escuela de Ingeniería y Ciencias, Ave. General Ramon Corona 2514, Zapopan 45138, Jalisco, Mexico.
ACS Omega. 2024 May 8;9(20):21891-21903. doi: 10.1021/acsomega.3c09633. eCollection 2024 May 21.
Metabolic syndrome is a condition characterized by metabolic alterations that culminate in chronic noncommunicable diseases of high morbidity and mortality, such as cardiovascular diseases, type 2 diabetes, nonalcoholic fatty liver disease, and colon cancer. Developing new therapeutic strategies with a multifactorial approach is important since current therapies focus on only one or two components of the metabolic syndrome. In this sense, plant-based gene regulation represents an innovative strategy to prevent or modulate human metabolic pathologies, including metabolic syndrome. Here, using a computational and systems biology approach, it was found that carrot microRNAs can modulate key BMPs/SMAD signaling members, C/EBPs, and KLFs involved in several aspects associated with metabolic syndrome, including the hsa04350:TGF-beta signaling pathway, hsa04931:insulin resistance, hsa04152:AMPK signaling pathway, hsa04933:AGE-RAGE signaling pathway in diabetic complications, hsa04010:MAPK signaling pathway, hsa04350:TGF-beta signaling pathway, hsa01522:endocrine resistance, and hsa04910:insulin signaling pathway. These data demonstrated the potential applications of carrot microRNAs as effective food-based therapeutics for obesity and associated metabolic diseases.
代谢综合征是一种以代谢改变为特征的病症，这些改变最终会导致高发病率和高死亡率的慢性非传染性疾病，如心血管疾病、2型糖尿病、非酒精性脂肪肝病和结肠癌。由于目前的治疗方法仅侧重于代谢综合征的一两个组成部分，因此采用多因素方法开发新的治疗策略很重要。从这个意义上讲，基于植物的基因调控是预防或调节人类代谢疾病（包括代谢综合征）的一种创新策略。在这里，使用计算和系统生物学方法发现，胡萝卜微小RNA可以调节与代谢综合征相关的几个方面所涉及的关键骨形态发生蛋白/信号转导分子母亲抵抗蛋白（BMPs/SMAD）信号成员、C/EBPs和Krüppel样因子（KLFs），包括hsa04350：转化生长因子-β（TGF-β）信号通路、hsa04931：胰岛素抵抗、hsa04152：腺苷酸活化蛋白激酶（AMPK）信号通路、hsa04933：糖尿病并发症中的晚期糖基化终末产物-晚期糖基化终末产物受体（AGE-RAGE）信号通路、hsa04010：丝裂原活化蛋白激酶（MAPK）信号通路、hsa04350：TGF-β信号通路、hsa01522：内分泌抵抗和hsa04910：胰岛素信号通路。这些数据证明了胡萝卜微小RNA作为肥胖及相关代谢疾病有效食物疗法的潜在应用。
