Ebrahimi Reyhane, Bahiraee Alireza, Niazpour Farshad, Emamgholipour Solaleh, Meshkani Reza
Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Students' Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran.
J Cell Biochem. 2019 Dec;120(12):19290-19309. doi: 10.1002/jcb.29299. Epub 2019 Jul 31.
Insulin resistance (IR) is a shared pathological condition among type 2 diabetes, obesity, cardiovascular disease, and other metabolic disorders. It is growing significantly all over the world and consequently, a substantial effort is needed for developing the potential novel diagnostics and therapeutics. An insulin signaling pathway is tightly modulated by different mechanisms including the epigenetic modifications. Today, a deal of great attention has been shifted towards the regulatory role of noncoding RNAs on target proteins of the insulin signaling pathway. Noncoding RNAs are a major area of the epigenetics which control gene expression at the posttranscriptional levels and include a large class of microRNAs (miRNAs). With this in view, many studies have implicated the mediatory effects of miRNAs on the downstream metabolic and mitogenic proteins of the insulin signaling pathway. Since providing new biomarkers for the early diagnosis of IR and related metabolic traits are very significant, we intended to review the possible role of miRNAs in the regulation of the insulin signaling pathway, with a primary focus on the downstream target proteins of the metabolic and mitogenic cascades.
胰岛素抵抗（IR）是2型糖尿病、肥胖症、心血管疾病及其他代谢紊乱的共同病理状态。它在全球范围内显著增加，因此，开发潜在的新型诊断方法和治疗手段需要付出巨大努力。胰岛素信号通路受到包括表观遗传修饰在内的不同机制的严格调控。如今，大量关注已转向非编码RNA对胰岛素信号通路靶蛋白的调节作用。非编码RNA是表观遗传学的一个主要领域，它在转录后水平控制基因表达，包括一大类微小RNA（miRNA）。鉴于此，许多研究表明miRNA对胰岛素信号通路下游代谢和促有丝分裂蛋白具有介导作用。由于为IR及相关代谢特征的早期诊断提供新的生物标志物非常重要，我们旨在综述miRNA在胰岛素信号通路调节中的可能作用，主要关注代谢和促有丝分裂级联反应的下游靶蛋白。
