Sharma Nava Raj, Basnet Arjun, Lamichhane Saral, Tiwari Kripa, Varghese Jeffy, Gautam Sudarshan, Pokhrel Madalasa
Manipal College of Medical Sciences Pokhara Nepal.
Maimonides Medical Center Brooklyn New York USA.
Clin Case Rep. 2024 May 24;12(6):e9016. doi: 10.1002/ccr3.9016. eCollection 2024 Jun.
Chronic ketamine use can lead to sphincter of oddi dysfunction (SOD), causing various hepatobiliary complications. Recognizing substance abuse history is vital for early detection. Timely intervention can prevent irreversible liver and pancreas damage.
Ketamine is commonly abused as a recreational drug worldwide due to its ability to induce euphoria-like effects. Ketamine abuse is associated with many hepatobiliary side effects ranging from cholestasis to biliary sepsis and death. Here we present a case of a young 29-year female with upper abdominal pain due to SOD resulting from chronic use of ketamine. SOD can result in obstruction or dysfunction of the bile and pancreatic ducts. Ketamine induces SOD by activation of the muscarinic receptors in the sphincter of oddi. Detail history of substance abuse is crucial for early identification of ketamine-induced SOD. Early identification and treatment of this rare condition can prevent permanent injury to the liver and pancreas.
长期使用氯胺酮可导致Oddi括约肌功能障碍（SOD），引发各种肝胆并发症。了解药物滥用史对于早期发现至关重要。及时干预可预防肝脏和胰腺的不可逆损伤。
氯胺酮因其能产生类似欣快感的效果，在全球范围内常被滥用为娱乐性药物。氯胺酮滥用与许多肝胆副作用相关，从胆汁淤积到胆源性败血症甚至死亡。在此，我们报告一例29岁年轻女性因长期使用氯胺酮导致SOD而出现上腹部疼痛的病例。SOD可导致胆管和胰管梗阻或功能障碍。氯胺酮通过激活Oddi括约肌中的毒蕈碱受体诱导SOD。详细的药物滥用史对于早期识别氯胺酮诱导的SOD至关重要。早期识别和治疗这种罕见病症可预防肝脏和胰腺的永久性损伤。
