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Ketamine Hepatotoxicity: An Underappreciated Cause of Liver Damage - Analysis by RUCAM.

作者信息

Thakkar Bianca, Wu George Y

机构信息

Department of Medicine, University of Connecticut Health Center, Farmington, CT, USA.

Department of Medicine, Division of Gastroenterology-Hepatology, University of Connecticut Health Center, Farmington, CT, USA.

出版信息

J Clin Transl Hepatol. 2025 Jun 28;13(6):524-531. doi: 10.14218/JCTH.2024.00478. Epub 2025 Apr 11.

DOI:10.14218/JCTH.2024.00478
PMID:40474883
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12134908/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8d0/12134908/bdf1a2e96267/JCTH-13-524-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8d0/12134908/bdf1a2e96267/JCTH-13-524-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8d0/12134908/bdf1a2e96267/JCTH-13-524-g001.jpg

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本文引用的文献

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Hepatic adverse events associated with ketamine and esketamine: A population-based disproportionality analysis.与氯胺酮和艾司氯胺酮相关的肝脏不良事件：一项基于人群的不成比例分析。
J Affect Disord. 2025 Apr 1;374:390-396. doi: 10.1016/j.jad.2025.01.054. Epub 2025 Jan 14.
2
Sphincter of oddi dysfunction induced by ketamine: A case report.氯胺酮诱发的Oddi括约肌功能障碍：一例报告。
Clin Case Rep. 2024 May 24;12(6):e9016. doi: 10.1002/ccr3.9016. eCollection 2024 Jun.
3
In Vitro Hepatotoxicity of Routinely Used Opioids and Sedative Drugs.
常用阿片类药物和镇静药物的体外肝毒性
Curr Issues Mol Biol. 2024 Mar 30;46(4):3022-3038. doi: 10.3390/cimb46040189.
4
A Case of Hepatotoxicity Induced by Therapeutic Ketamine Use for Sedation.一例因治疗性使用氯胺酮镇静导致肝毒性的病例。
Case Rep Crit Care. 2024 Mar 12;2024:8366034. doi: 10.1155/2024/8366034. eCollection 2024.
5
Ketamine restriction correlates with reduced cholestatic liver injury and improved outcomes in critically ill patients with burn injury.氯胺酮限制与烧伤重症患者胆汁淤积性肝损伤减轻及预后改善相关。
JHEP Rep. 2023 Nov 2;6(2):100950. doi: 10.1016/j.jhepr.2023.100950. eCollection 2024 Feb.
6
Secondary Sclerosing Cholangitis After SARS-CoV2: ICU Ketamine Use or Virus-Specific Biliary Tropism and Injury in the Context of Biliary Ischemia in Critically Ill Patients?新型冠状病毒肺炎后的继发性硬化性胆管炎：危重症患者在胆汁缺血情况下使用重症监护病房氯胺酮还是病毒特异性胆管嗜性及损伤？
Hepat Med. 2023 Aug 1;15:93-112. doi: 10.2147/HMER.S384220. eCollection 2023.
7
Characteristics of poisonings involving ketamine in the United States, 2019-2021.2019-2021 年美国涉及氯胺酮中毒的特点。
J Psychopharmacol. 2023 Aug;37(8):802-808. doi: 10.1177/02698811221140006. Epub 2022 Dec 7.
8
Long-term ketamine infusion-induced cholestatic liver injury in COVID-19-associated acute respiratory distress syndrome.长期输注氯胺酮诱导 COVID-19 相关急性呼吸窘迫综合征的胆汁淤积性肝损伤。
Crit Care. 2022 May 23;26(1):148. doi: 10.1186/s13054-022-04019-8.
9
Ketamine: From Prescription Anaesthetic to a New Psychoactive Substance.氯胺酮：从处方麻醉剂到新型精神活性物质。
Curr Pharm Des. 2022;28(15):1213-1220. doi: 10.2174/1381612828666220510115209.
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J Psychoactive Drugs. 2023 Apr-Jun;55(2):134-140. doi: 10.1080/02791072.2022.2058896. Epub 2022 Mar 29.