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托珠单抗治疗背景下的脾包膜下脓肿及相关脓胸：一例报告

subcapsular splenic abscess and associated empyema in the setting of tocilizumab therapy: A case report.

作者信息

Lee Audrey, Aw Yi Tong Vincent

机构信息

General Medicine Department Canberra Hospital, Canberra Health Services Canberra Australian Capital Territory Australia.

Australian National University Medical School, School of Medicine and Psychology Australian National University Canberra Australian Capital Territory Australia.

出版信息

Clin Case Rep. 2024 May 24;12(6):e8997. doi: 10.1002/ccr3.8997. eCollection 2024 Jun.

DOI:10.1002/ccr3.8997
PMID:38799529
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11126640/
Abstract

We report a case of subcapsular splenic abscess and associated empyema after recent commencement of tocilizumab, masquerading as musculoskeletal pain. This highlights the importance of considering unusual underlying infections in patients on tocilizumab.

摘要

我们报告了一例在近期开始使用托珠单抗后出现脾包膜下脓肿及相关脓胸的病例，该病例最初表现为肌肉骨骼疼痛。这凸显了在使用托珠单抗的患者中考虑罕见潜在感染的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e940/11126640/f3f29a5c1768/CCR3-12-e8997-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e940/11126640/ac996ad8a91e/CCR3-12-e8997-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e940/11126640/f3f29a5c1768/CCR3-12-e8997-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e940/11126640/ac996ad8a91e/CCR3-12-e8997-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e940/11126640/f3f29a5c1768/CCR3-12-e8997-g003.jpg

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本文引用的文献

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Efficacy and secondary infection risk of tocilizumab, sarilumab and anakinra in COVID-19 patients: A systematic review and meta-analysis.托珠单抗、沙利鲁单抗和阿那白滞素治疗 COVID-19 患者的疗效和二次感染风险：系统评价和荟萃分析。
Rev Med Virol. 2022 May;32(3):e2295. doi: 10.1002/rmv.2295. Epub 2021 Sep 24.
2
The Effect of Tocilizumab on Inflammatory Markers in Patients Hospitalized with Serious Infections. Case Series and Review of Literature.托珠单抗对因严重感染住院患者炎症标志物的影响。病例系列及文献综述。
Life (Basel). 2021 Mar 20;11(3):258. doi: 10.3390/life11030258.
3
Late onset infectious complications and safety of tocilizumab in the management of COVID-19.
COVID-19 管理中托珠单抗的迟发性感染并发症和安全性。
J Med Virol. 2021 Mar;93(3):1459-1464. doi: 10.1002/jmv.26429. Epub 2020 Aug 21.
4
Tuberculosis sepsis after tocilizumab treatment.托珠单抗治疗后发生结核败血症。
Clin Microbiol Infect. 2020 Nov;26(11):1493-1494. doi: 10.1016/j.cmi.2020.05.030. Epub 2020 Jun 5.
5
Risk of serious infections in tocilizumab versus other biologic drugs in patients with rheumatoid arthritis: a multidatabase cohort study.托珠单抗与其他生物制剂治疗类风湿关节炎患者的严重感染风险：多数据库队列研究。
Ann Rheum Dis. 2019 Apr;78(4):456-464. doi: 10.1136/annrheumdis-2018-214367. Epub 2019 Jan 24.
6
Three cases of severely disseminated Staphylococcus aureus infection in patients treated with tocilizumab.3例使用托珠单抗治疗的患者发生严重播散性金黄色葡萄球菌感染。
BMJ Case Rep. 2013 Jan 2;2013:bcr2012007413. doi: 10.1136/bcr-2012-007413.
7
Crossing the barrier: when the diaphragm is not a limit.穿越障碍：当横膈膜不再是限制。
AJR Am J Roentgenol. 2013 Jan;200(1):W62-70. doi: 10.2214/AJR.11.8264.
8
The risk of infections associated with rheumatoid arthritis, with its comorbidity and treatment.与类风湿关节炎相关的感染风险，及其合并症和治疗。
Rheumatology (Oxford). 2013 Jan;52(1):53-61. doi: 10.1093/rheumatology/kes305. Epub 2012 Nov 28.
9
Risk of adverse events including serious infections in rheumatoid arthritis patients treated with tocilizumab: a systematic literature review and meta-analysis of randomized controlled trials.托珠单抗治疗类风湿关节炎患者不良事件（包括严重感染）风险的系统文献回顾和荟萃分析：随机对照试验。
Rheumatology (Oxford). 2011 Mar;50(3):552-62. doi: 10.1093/rheumatology/keq343. Epub 2010 Nov 14.
10
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