Fu Lingyu, Wang Shiying, Wang Yingyan, Zhang Haiyan
Department of Gastroenterology The Second Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou China.
Department of Clinical Pharmacy The Second Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou China.
Clin Case Rep. 2024 May 24;12(6):e8998. doi: 10.1002/ccr3.8998. eCollection 2024 Jun.
Administering azathioprine or infliximab for UC and AS treatment carries a significant risk of adverse reactions. Here, we present the case diagnosed with UC and AS, who received treatment with azathioprine and infliximab for 10 months, and subsequently developed drug-induced myopathy affecting the right vastus medialis muscle.
Drug-induced myopathy is an uncommon form of muscle injury that can arise in patients without preexisting muscle conditions when exposed to therapeutic doses of certain medications. Administering azathioprine or infliximab for ulcerative colitis (UC) and ankylosing spondylitis (AS) treatment carries a significant risk of adverse reactions, including drug-induced myopathy and increased susceptibility to opportunistic infections. However, occurrences of myopathy induced by the combination of azathioprine and infliximab are rarely reported in clinical practice. Here, we present the case of a 37-year-old male patient diagnosed with UC and AS, who received treatment with azathioprine and infliximab for 10 months. Despite the resolution of symptoms and improvement in intestinal mucosal inflammation observed via endoscopy, the patient subsequently developed drug-induced myopathy affecting the right vastus medialis muscle.
使用硫唑嘌呤或英夫利昔单抗治疗溃疡性结肠炎（UC）和强直性脊柱炎（AS）存在显著不良反应风险。在此，我们报告一例被诊断为UC和AS的患者，其接受硫唑嘌呤和英夫利昔单抗治疗10个月后，继发药物性肌病，累及右侧股内侧肌。
药物性肌病是一种罕见的肌肉损伤形式，可发生于既往无肌肉疾病的患者在接受某些治疗剂量药物时。使用硫唑嘌呤或英夫利昔单抗治疗溃疡性结肠炎（UC）和强直性脊柱炎（AS）存在显著不良反应风险，包括药物性肌病和机会性感染易感性增加。然而，硫唑嘌呤和英夫利昔单抗联合诱发肌病在临床实践中鲜有报道。在此，我们报告一例37岁男性患者，被诊断为UC和AS，接受硫唑嘌呤和英夫利昔单抗治疗10个月。尽管症状缓解且内镜检查显示肠道黏膜炎症改善，但该患者随后继发药物性肌病，累及右侧股内侧肌。
